Comparison of 6-Month Outcomes of Survivors of COVID-19 versus Non-COVID-19 Critical Illness.

2022-05-15

Hodgson, Carol L

Higgins, Alisa M

Bailey, Michael J

Mather, Anne M

Beach, Lisa

Bellomo, Rinaldo

Bissett, Bernie

Boden, Ianthe J

Bradley, Scott

Burrell, Aidan

Cooper, D James

Fulcher, Bentley J

Haines, Kimberley J

Hodgson, Isabelle T

Hopkins, Jack

Jones, Alice Y M

Lane, Stuart

Lawrence, Drew

van der Lee, Lisa

Liacos, Jennifer

Linke, Natalie J

Gomes, Lonni Marques

Nickels, Marc

Ntoumenopoulos, George

Myles, Paul S

Patman, Shane

Paton, Michelle

Pound, Gemma

Rai, Sumeet

Rix, Alana

Rollinson, Thomas C

Tipping, Claire J

Thomas, Peter

Trapani, Tony

Udy, Andrew A

Whitehead, Christina

Anderson, Shannah

Neto, Ary Serpa

SARS-CoV-2

critical care

long COVID

long-term outcomes

recovery

Journal Article

0000-0001-9002-2075

0000-0002-1650-8939

0000-0003-1520-9387

0000-0001-8973-661X

10.1164/rccm.202110-2335OC

Rationale: The outcomes of survivors of critical illness due to coronavirus disease (COVID-19) compared with non-COVID-19 are yet to be established. Objectives: We aimed to investigate new disability at 6 months in mechanically ventilated patients admitted to Australian ICUs with COVID-19 compared with non-COVID-19. Methods: We included critically ill patients with COVID-19 and non-COVID-19 from two prospective observational studies. Patients were eligible if they were adult (age ⩾ 8 yr) and received ⩾24 hours of mechanical ventilation. In addition, patients with COVID-19 were eligible with a positive laboratory PCR test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Measurements and Main Results: Demographic, intervention, and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0. Between March 6, 2020, and April 21, 2021, 120 critically ill patients with COVID-19, and between August 2017 and January 2019, 199 critically ill patients without COVID-19, fulfilled the inclusion criteria. Patients with COVID-19 were older (median [interquartile range], 62 [55-71] vs. 58 [44-69] yr; P = 0.019) with a lower Acute Physiology and Chronic Health Evaluation II score (17 [13-20] vs. 19 [15-23]; P = 0.011). Although duration of ventilation was longer in patients with COVID-19 than in those without COVID-19 (12 [5-19] vs. 4.8 [2.3-8.8] d; P < 0.001), 180-day mortality was similar between the groups (39/120 [32.5%] vs. 70/199 [35.2%]; P = 0.715). The incidence of death or new disability at 180 days was similar (58/93 [62.4%] vs. 99/150 [66/0%]; P = 0.583). Conclusions: At 6 months, there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared with non-COVID-19. Clinical trial registered with www.clinicaltrials.gov (NCT04401254).

link

American Journal of Respiratory and Critical Care Medicine 2022; 205(10): 1159-1168

American Journal of Respiratory and Critical Care Medicine