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Title: Sleep-disordered breathing was associated with lower health-related quality of life and cognitive function in a cross-sectional study of older adults.
Austin Authors: Ward, Stephanie A;Storey, Elsdon;Gasevic, Danijela;Naughton, Matthew T;Hamilton, Garun S;Trevaks, Ruth E;Wolfe, Rory;O'Donoghue, Fergal J ;Stocks, Nigel;Abhayaratna, Walter P;Fitzgerald, Sharyn;Orchard, Suzanne G;Ryan, Joanne;McNeil, John J;Reid, Christopher M;Woods, Robyn L
Affiliation: Institute for Breathing and Sleep
College of Health and Medicine, Australian National University, Acton, Australian Capital Territory, Australia
School of Clinical Sciences, Monash University, Clayton, Victoria, Australia
Curtin School of Population Health, Curtin University, Perth, Western Australia
Academic Unit of Internal Medicine, Canberra Hospital, Garran, Australia
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria
Department of Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
The Central Clinical School, Monash University, Melbourne, Victoria, Australia
Department of Lung, Sleep, Allergy and Immunology, Monash Health, Clayton, Victoria, Australia
Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Kensington, New South Wales
Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia
Discipline of General Practice, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
Department of Geriatric Medicine, Prince of Wales Hospital, Randwick, New South Wales
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria..
Centre for Global Health Research, Usher Institute, The University of Edinburgh, Edinburgh, UK
Issue Date: 17-May-2022
Date: 2022
Publication information: Respirology (Carlton, Vic.) 2022; 27(9): 767-775
Abstract: The clinical significance of sleep-disordered breathing (SDB) in older age is uncertain. This study determined the prevalence and associations of SDB with mood, daytime sleepiness, quality of life (QOL) and cognition in a relatively healthy older Australian cohort. A cross-sectional analysis was conducted from the Study of Neurocognitive Outcomes, Radiological and retinal Effects of Aspirin in Sleep Apnoea. Participants completed an unattended limited channel sleep study to measure the oxygen desaturation index (ODI) to define mild (ODI 5-15) and moderate/severe (ODI ≥ 15) SDB, the Centre for Epidemiological Studies Scale, the Epworth Sleepiness Scale, the 12-item Short-Form for QOL and neuropsychological tests. Of the 1399 participants (mean age 74.0 years), 36% (273 of 753) of men and 25% (164 of 646) of women had moderate/severe SDB. SDB was associated with lower physical health-related QOL (mild SDB: beta coefficient [β] -2.5, 95% CI -3.6 to -1.3, p < 0.001; moderate/severe SDB: β -1.8, 95% CI -3.0 to -0.6, p = 0.005) and with lower global composite cognition (mild SDB: β -0.1, 95% CI -0.2 to 0.0, p = 0.022; moderate/severe SDB: β -0.1, 95% CI -0.2 to 0.0, p = 0.032) compared to no SDB. SDB was not associated with daytime sleepiness nor depression. SDB was associated with lower physical health-related quality of life and cognitive function. Given the high prevalence of SDB in older age, assessing QOL and cognition may better delineate subgroups requiring further management, and provide useful treatment target measures for this age group.
DOI: 10.1111/resp.14279
Journal: Respirology (Carlton, Vic.)
PubMed URL: 35580042
PubMed URL:
Type: Journal Article
Subjects: ageing
quality of life
sleep-disordered breathing
Appears in Collections:Journal articles

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