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Title: Is Sleep Disordered Breathing Confounding Rehabilitation Outcomes in Spinal Cord Injury Research?
Austin Authors: Panza, Gino S;Sutor, Tommy;Gee, Cameron M;Graco, Marnie ;McCully, Kevin K;Chiodo, Anthony;Badr, M Safwan;Nash, Mark S
Affiliation: Institute for Breathing and Sleep
School of Physiotherapy, University of Melbourne, Melbourne, Australia
Research Service, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA
International Collaboration on Repair Discoveries, Vancouver, BC, Canada
Kinesiology, University of Georgia, Athens, GA
Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI
Department of Neurological Surgery, Physical Medicine & Rehabiliation, and Physical Therapy, Miami, FL; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL
John D. Dingell Veterans Affairs Medical Center, Detroit, MI
Department of Physiology, Wayne State University School of Medicine, Detroit, MI
Issue Date: May-2022 2021-09-17
Publication information: Archives of Physical Medicine and Rehabilitation 2022; 103(5): 1034-1045
Abstract: The purpose of this article is to highlight the importance of considering sleep-disordered breathing (SDB) as a potential confounder to rehabilitation research interventions in spinal cord injury (SCI). SDB is highly prevalent in SCI, with increased prevalence in individuals with higher and more severe lesions, and the criterion standard treatment with continuous positive airway pressure remains problematic. Despite its high prevalence, SDB is often untested and untreated in individuals with SCI. In individuals without SCI, SDB is known to negatively affect physical function and many of the physiological systems that negatively affect physical rehabilitation in SCI. Thus, owing to the high prevalence, under testing, low treatment adherence, and known negative effect on the physical function, it is contended that underdiagnosed SDB in SCI may be confounding physical rehabilitation research studies in individuals with SCI. Studies investigating the effect of treating SDB and its effect on physical rehabilitation in SCI were unable to be located. Thus, studies investigating the likely integrated relationship among physical rehabilitation, SDB, and proper treatment of SDB in SCI are needed. Owing to rapid growth in both sleep medicine and physical rehabilitation intervention research in SCI, the authors contend it is the appropriate time to begin the conversations and collaborations between these fields. We discuss a general overview of SDB and physical training modalities, as well as how SDB could be affecting these studies.
DOI: 10.1016/j.apmr.2021.08.015
ORCID: 0000-0001-6048-0147
Journal: Archives of Physical Medicine and Rehabilitation
PubMed URL: 34537222
PubMed URL:
Type: Journal Article
Subjects: Rehabilitation
Sleep apnea syndromes
Spinal cord injuries
Appears in Collections:Journal articles

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