Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum.

2022-04-05

Doré, Vincent

Doecke, James D

Saad, Ziad S

Triana-Baltzer, Gallen

Slemmon, Randy

Krishnadas, Natasha

Bourgeat, Pierrick

Huang, Kun

Burnham, Samantha

Fowler, Christopher

Rainey-Smith, Stephanie R

Bush, Ashley I

Ward, Larry

Robertson, Jo

Martins, Ralph N

Masters, Colin L

Villemagne, Victor L

Fripp, Jurgen

Kolb, Hartmuth C

Rowe, Christopher C

Alzheimer's disease

Aβ imaging

amyloid imaging

amyloid plaque

blood biomarkers

blood diagnostic for Alzheimer's disease

paired helical filaments

phosphorylated tau

plasma P‐tau217

positron emission tomography

tau imaging

Journal Article

https://orcid.org/0000-0002-8051-0558

https://orcid.org/0000-0002-5374-2839

https://orcid.org/0000-0003-1397-0359

https://orcid.org/0000-0001-8259-9069

https://orcid.org/0000-0003-3072-7940

https://orcid.org/0000-0002-5832-9875

https://orcid.org/0000-0003-3910-2453

10.1002/dad2.12307

We evaluated a new Simoa plasma assay for phosphorylated tau (P-tau) at aa217 enhanced by additional p-tau sites (p217+tau). Plasma p217+tau levels were compared to 18F-NAV4694 amyloid beta (Aβ) positron emission tomography (PET) and 18F-MK6240 tau PET in 174 cognitively impaired (CI) and 223 cognitively unimpaired (CU) participants. Compared to Aβ- CU, the plasma levels of p217+tau increased 2-fold in Aβ+ CU and 3.5-fold in Aβ+ CI. In Aβ- the p217+tau levels did not differ significantly between CU and CI. P217+tau correlated with Aβ centiloids P = .67 (CI, P = .64; CU, P = .45) and tau SUVRMT P = .63 (CI, P = .69; CU, P = .34). Area under curve (AUC) for Alzheimer's disease (AD) dementia versus Aβ- CU was 0.94, for AD dementia versus other dementia was 0.93, for Aβ+ versus Aβ- PET was 0.89, and for tau+ versus tau- PET was 0.89. Plasma p217+tau levels elevate early in the AD continuum and correlate well with Aβ and tau PET.

link

Alzheimer's & Dementia (Amsterdam, Netherlands) 2022; 14(1): e12307

Alzheimer's & Dementia (Amsterdam, Netherlands)

2352-8729