Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/29721
Title: In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group.
Austin Authors: Haukvik, Unn K;Gurholt, Tiril P;Nerland, Stener;Elvsåshagen, Torbjørn;Akudjedu, Theophilus N;Alda, Martin;Alnaes, Dag;Alonso-Lana, Silvia;Bauer, Jochen;Baune, Bernhard T;Benedetti, Francesco;Berk, Michael;Bettella, Francesco;Bøen, Erlend;Bonnín, Caterina M;Brambilla, Paolo;Canales-Rodríguez, Erick J;Cannon, Dara M;Caseras, Xavier;Dandash, Orwa;Dannlowski, Udo;Delvecchio, Giuseppe;Díaz-Zuluaga, Ana M;van Erp, Theo G M;Fatjó-Vilas, Mar;Foley, Sonya F;Förster, Katharina;Fullerton, Janice M;Goikolea, José M;Grotegerd, Dominik;Gruber, Oliver;Haarman, Bartholomeus C M;Haatveit, Beathe;Hajek, Tomas;Hallahan, Brian;Harris, Mathew;Hawkins, Emma L;Howells, Fleur M;Hülsmann, Carina;Jahanshad, Neda;Jørgensen, Kjetil N;Kircher, Tilo;Krämer, Bernd;Krug, Axel;Kuplicki, Rayus;Lagerberg, Trine V;Lancaster, Thomas M;Lenroot, Rhoshel K;Lonning, Vera;López-Jaramillo, Carlos;Malt, Ulrik F;McDonald, Colm;McIntosh, Andrew M;McPhilemy, Genevieve;van der Meer, Dennis;Melle, Ingrid;Melloni, Elisa M T;Mitchell, Philip B;Nabulsi, Leila;Nenadić, Igor;Oertel, Viola;Oldani, Lucio;Opel, Nils;Otaduy, Maria C G;Overs, Bronwyn J;Pineda-Zapata, Julian A;Pomarol-Clotet, Edith;Radua, Joaquim;Rauer, Lisa;Redlich, Ronny;Repple, Jonathan;Rive, Maria M;Roberts, Gloria;Ruhe, Henricus G;Salminen, Lauren E;Salvador, Raymond;Sarró, Salvador;Savitz, Jonathan;Schene, Aart H;Sim, Kang;Soeiro-de-Souza, Marcio G;Stäblein, Michael;Stein, Dan J;Stein, Frederike;Tamnes, Christian K;Temmingh, Henk S;Thomopoulos, Sophia I;Veltman, Dick J;Vieta, Eduard;Waltemate, Lena;Westlye, Lars T;Whalley, Heather C;Sämann, Philipp G;Thompson, Paul M;Ching, Christopher R K;Andreassen, Ole A;Agartz, Ingrid
Affiliation: Department of Adult Mental Health, Institute of Clinical Medicine, University of Oslo, Oslo, Norway...
Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway..
Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway..
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway..
Department of Neurology, Oslo University Hospital, Oslo, Norway..
Institute of Clinical Medicine, University of Oslo, Oslo, Norway..
Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland..
Institute of Medical Imaging & Visualisation, Faculty of Health & Social Sciences, Bournemouth University, Bournemouth, UK..
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada..
National Institute of Mental Health, Klecany, Czech Republic..
FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain..
Institute of Clinical Radiology, University of Münster, Münster, Germany..
Department of Psychiatry, University of Münster, Münster, Germany..
Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Australia..
The Florey Institute of Neuroscience and Mental Health
Psychiatry and Clinical Psychobiology, Scientific Institute Ospedale San Raffaele, Milan, Italy..
University Vita-Salute San Raffaele, Milan, Italy..
Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Victoria, Australia..
Orygen, The National Centre of Excellence in Youth Mental Health and Centre for Youth Mental Health, the Department of Psychiatry and the Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia..
Psychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway..
Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain..
Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy..
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy..
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK..
Brain, Mind and Society Research Hub, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia..
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia..
Research Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia..
Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, USA..
Center for the Neurobiology of Learning, University of California Irvine and Memory, Irvine, California, USA..
Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK..
Neuroscience Research Australia, Randwick, New South Wales, Australia..
School of Medical Sciences, The University of New South Wales, Sydney, New South Wales, Australia..
Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany..
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands..
Division of Psychiatry, University of Edinburgh, Edinburgh, UK..
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa..
Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa..
Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA..
Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany..
Center for Mind, Brain and Behavior (CMBB), Marburg, Germany..
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany..
Laureate Institute for Brain Research, Tulsa, Oklahoma, USA..
School of Psychology, Bath University, Bath, UK..
School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia..
University of New Mexico, Albuquerque, New Mexico, USA..
Mood Disorders Program, Hospital Universitario San Vicente Fundación, Medellín, Antioquia, Colombia..
School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands..
Black Dog Institute, Sydney, New South Wales, Australia..
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany..
LIM44, Department of Radiology and Oncology, University of São Paulo, São Paulo, Brazil..
Research Group, Instituto de Alta Tecnología Médica, Medellín, Antioquia, Colombia..
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain..
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK..
Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden..
Psychiatry, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands..
Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands..
Department of Psychiatry, Radboudumc, Nijmegen, The Netherlands..
Oxley College of Health Sciences, The University of Tulsa, Tulsa, Oklahoma, USA..
West Region/Institute of Mental Health, Singapore, Singapore..
Yong Loo Lin School of Medicine/National University of Singapore, Singapore, Singapore..
Lee Kong Chian School of Medicine/Nanyang Technological University, Singapore, Singapore..
Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil..
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa..
PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway..
General Adult Psychiatry Division, Valkenberg Hospital, Cape Town, Western Cape, South Africa..
Department of Psychiatry, Amsterdam UMC, Location VUMC, Amsterdam, The Netherlands..
Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands..
Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain..
Department of Psychology, University of Oslo, Oslo, Norway..
Max Planck Institute of Psychiatry, Munich, Germany..
Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden..
Issue Date: Jan-2022
Date: 2020
Publication information: Human Brain Mapping 2022; 43(1): 385-398
Abstract: The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.
URI: https://ahro.austin.org.au/austinjspui/handle/1/29721
DOI: 10.1002/hbm.25249
ORCID: 0000-0002-0363-4127
0000-0002-1272-7616
0000-0002-1145-9103
0000-0003-1322-2449
0000-0002-0749-7473
0000-0003-1240-5438
0000-0002-7018-4525
0000-0003-1379-9491
0000-0001-5557-1562
0000-0002-0046-4070
0000-0001-8644-956X
0000-0001-8523-3628
0000-0001-6548-426X
0000-0002-5554-6946
Journal: Human Brain Mapping
PubMed URL: 33073925
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/33073925/
Type: Journal Article
Subjects: bipolar disorder subtype
hippocampus
large-scale
lithium
psychosis
structural brain MRI
Appears in Collections:Journal articles

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