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Title: Premedication Protocols to Prevent Hypersensitivity Reactions to Chemotherapy: a Literature Review.
Austin Authors: ALMuhizi, Faisal;De Las Vecillas Sanchez, Leticia;Gilbert, Lucy;Copaescu, Ana ;Isabwe, Ghislaine A C
Affiliation: Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre (MUHC), McGill University, Montreal, QC, Canada..
The Research Institute, McGill University Health Centre, McGill University, Montreal, QC, Canada..
Department of Allergy, La Paz University Hospital, Madrid, Spain..
Department of Oncology, Obstetrics and Gynecology, McGill University Health Center (MUHC), McGill University, Montreal, QC, Canada..
Centre for Antibiotic Allergy and Research
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Security Forces Hospital Program, Riyadh, Saudi Arabia..
Infectious Diseases
Issue Date: Jun-2022
Date: 2022-03-08
Publication information: Clinical Reviews in Allergy & Immunology 2022; 62(3): 534-547
Abstract: Hypersensitivity reactions (HSRs) to chemotherapy may prevent patients from receiving the most effective therapy. This review was undertaken to identify evidence-based preventive premedication strategies that reduce the likelihood of HSR in the first instance and improve the safety of subsequent infusions in patients who have demonstrated HSR to a certain class of chemotherapy. PubMed was searched until October 2021 using the key words: "hypersensitivity to chemotherapeutic drugs," "hypersensitivity to antineoplastic agents," "taxanes hypersensitivity," "platinum compound hypersensitivity," "premedication," "dexamethasone," "prednisone," "hydrocortisone," "antihistamine," "diphenhydramine," "cetirizine," "famotidine," "meperidine," "aspirin," "ibuprofen," and "montelukast." The search was restricted to articles published in English. A total of 73 abstracts were selected for inclusion in the review. Most premedication regimens have been derived empirically rather than determined through randomized trials. Based on the available evidence, we provide an update on likely HSR mechanisms and a practical guide for classifying systemic HSR. The evidence indicates that a combination of prevention strategies using newer antihistamines, H2 antagonists, leukotriene receptor antagonists, and corticosteroids and other interventions used judiciously reduces the occurrence and severity of HSR and improves safety.
DOI: 10.1007/s12016-022-08932-2
Journal: Clinical reviews in allergy & immunology
PubMed URL: 35258842
PubMed URL:
Type: Journal Article
Subjects: Allergy
Hypersensitivity reaction
Appears in Collections:Journal articles

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