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|Title:||Association between amyloid-beta deposition and cortical thickness in dementia with Lewy bodies.||Austin Authors:||Chin, Kai Sin;Gajamange, Sanuji;Desmond, Patricia M;Villemagne, Victor L ;Rowe, Christopher C ;Churilov, Leonid ;Yassi, Nawaf;Watson, Rosie||Affiliation:||Molecular Imaging and Therapy
Departments of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia..
Department of Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia..
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA..
Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia..
Department of Aged Care, The Royal Melbourne Hospital, Parkville, VIC, Australia..
Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia..
|Issue Date:||Apr-2023||Date:||2022||Publication information:||The Australian and New Zealand journal of psychiatry 2023; 57(4)||Abstract:||Amyloid-beta often co-exists in dementia with Lewy bodies, but its clinical relevance in dementia with Lewy bodies remains unclear. This study aimed to investigate the clinical and imaging correlates of amyloid-beta deposition in dementia with Lewy bodies, particularly its relationship with cortical thickness in Alzheimer's disease-prone regions and hippocampal volume. Twenty-four participants with probable dementia with Lewy bodies underwent high-resolution magnetic resonance imaging and amyloid-beta positron emission tomography imaging using the radiotracer 18F-NAV4694. Amyloid-beta deposition was quantified and reported using the Centiloid method. Amyloid-beta positivity, defined as Centiloid > 50, was present in 45.8% of dementia with Lewy bodies participants. There were no statistically significant differences in clinical characteristics between Aβ+ and Aβ- dementia with Lewy bodies. Compared with the Aβ- group, Aβ+ dementia with Lewy bodies exhibited greater global cortical thinning as well as in the Alzheimer's disease-prone region of interest, adjusted for age, sex and years of education. A mean cortical thickness of 5.12 mm across a combined meta-region of interest has a sensitivity of 88.9% and specificity of 90.0% in discriminating Aβ+ from Aβ- dementia with Lewy bodies. Hippocampal volume was not different between groups. Early structural changes in cortical thickness, but not hippocampal volume, were observed in dementia with Lewy bodies with significant amyloid-beta burden. This may represent an early Alzheimer's disease-related neurodegenerative process.||URI:||https://ahro.austin.org.au/austinjspui/handle/1/28904||DOI:||10.1177/00048674221081773||ORCID:||https://orcid.org/0000-0002-3384-3499
|Journal:||The Australian and New Zealand journal of psychiatry||PubMed URL:||35196886||PubMed URL:||https://pubmed.ncbi.nlm.nih.gov/35196886/||Type:||Journal Article||Subjects:||Alzheimer’s disease
Dementia with Lewy bodies
|Appears in Collections:||Journal articles|
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checked on Dec 1, 2023
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