Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28794
Title: Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group.
Austin Authors: Han, Laura K M;Dinga, Richard;Hahn, Tim;Ching, Christopher R K;Eyler, Lisa T;Aftanas, Lyubomir;Aghajani, Moji;Aleman, André;Baune, Bernhard T;Berger, Klaus;Brak, Ivan;Filho, Geraldo Busatto;Carballedo, Angela;Connolly, Colm G;Couvy-Duchesne, Baptiste;Cullen, Kathryn R;Dannlowski, Udo;Davey, Christopher G;Dima, Danai;Duran, Fabio L S;Enneking, Verena;Filimonova, Elena;Frenzel, Stefan;Frodl, Thomas;Fu, Cynthia H Y;Godlewska, Beata R;Gotlib, Ian H;Grabe, Hans J;Groenewold, Nynke A;Grotegerd, Dominik;Gruber, Oliver;Hall, Geoffrey B;Harrison, Ben J;Hatton, Sean N;Hermesdorf, Marco;Hickie, Ian B;Ho, Tiffany C;Hosten, Norbert;Jansen, Andreas;Kähler, Claas;Kircher, Tilo;Klimes-Dougan, Bonnie;Krämer, Bernd;Krug, Axel;Lagopoulos, Jim;Leenings, Ramona;MacMaster, Frank P;MacQueen, Glenda;McIntosh, Andrew;McLellan, Quinn;McMahon, Katie L;Medland, Sarah E;Mueller, Bryon A;Mwangi, Benson;Osipov, Evgeny;Portella, Maria J;Pozzi, Elena;Reneman, Liesbeth;Repple, Jonathan;Rosa, Pedro G P;Sacchet, Matthew D;Sämann, Philipp G;Schnell, Knut;Schrantee, Anouk;Simulionyte, Egle;Soares, Jair C;Sommer, Jens;Stein, Dan J;Steinsträter, Olaf;Strike, Lachlan T;Thomopoulos, Sophia I;van Tol, Marie-José;Veer, Ilya M;Vermeiren, Robert R J M;Walter, Henrik;van der Wee, Nic J A;van der Werff, Steven J A;Whalley, Heather;Winter, Nils R;Wittfeld, Katharina;Wright, Margaret J;Wu, Mon-Ju;Völzke, Henry;Yang, Tony T;Zannias, Vasileios;de Zubicaray, Greig I;Zunta-Soares, Giovana B;Abé, Christoph;Alda, Martin;Andreassen, Ole A;Bøen, Erlend;Bonnin, Caterina M;Canales-Rodriguez, Erick J;Cannon, Dara;Caseras, Xavier;Chaim-Avancini, Tiffany M;Elvsåshagen, Torbjørn;Favre, Pauline;Foley, Sonya F;Fullerton, Janice M;Goikolea, Jose M;Haarman, Bartholomeus C M;Hajek, Tomas;Henry, Chantal;Houenou, Josselin;Howells, Fleur M;Ingvar, Martin;Kuplicki, Rayus;Lafer, Beny;Landén, Mikael;Machado-Vieira, Rodrigo;Malt, Ulrik F;McDonald, Colm;Mitchell, Philip B;Nabulsi, Leila;Otaduy, Maria Concepcion Garcia;Overs, Bronwyn J;Polosan, Mircea;Pomarol-Clotet, Edith;Radua, Joaquim;Rive, Maria M;Roberts, Gloria;Ruhe, Henricus G;Salvador, Raymond;Sarró, Salvador;Satterthwaite, Theodore D;Savitz, Jonathan;Schene, Aart H;Schofield, Peter R;Serpa, Mauricio H;Sim, Kang;Soeiro-de-Souza, Marcio Gerhardt;Sutherland, Ashley N;Temmingh, Henk S;Timmons, Garrett M;Uhlmann, Anne;Vieta, Eduard;Wolf, Daniel H;Zanetti, Marcus V;Jahanshad, Neda;Thompson, Paul M;Veltman, Dick J;Penninx, Brenda W J H;Marquand, Andre F;Cole, James H;Schmaal, Lianne
Affiliation: The Florey Institute of Neuroscience and Mental Health
Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK
Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia
Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia
Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia
Sunshine Coast Mind and Neuroscience Institute, University of the Sunshine Coast QLD, Sippy Downs, QLD, Australia
Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, VIC, Australia
Youth Mental Health Team, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia
QIMR Berghofer Medical Research Instititute, Brisbane, QLD, Australia
Neuroscience Research Australia, Randwick, Sydney, NSW, Australia
School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia
Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia
School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
School of Psychiatry, University of New South Wales, Kingsford, Sydney, NSW, Australia
Black Dog Institute, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia
Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Neurology, Oslo University Hospital, Oslo, Norway
Department of Neuroscience, Novosibirsk State University, Novosibirsk, Russia
Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands
Department of Psychology, School of Arts and Social Sciences, City, University of London, London, UK
Department for Psychiatry, Trinity College Dublin, Dublin, Ireland
Department of Psychiatry and Psychotherapy, Otto von Guericke University (OVGU), Magdeburg, Germany
German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany
Centre for Affective Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
German Center of Neurodegenerative Diseases (DZNE) Site Rostock/Greifswald, Greifswald, Germany
Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
Departments of Psychiatry and Pediatrics, University of Calgary, Calgary, AB, Canada
Addictions and Mental Health Strategic Clinical Network, Calgary, AB, Canada
Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany
Department of Psychiatry and Psychotherapy, Asklepios Fachklinikum Göttingen, Göttingen, Germany
SA MRC Unit on Risk and Resilience, University of Cape Town, Cape Town, South Africa
Department of Child Psychiatry, University Medical Center, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA
Department of Psychology, Stanford University, Stanford, CA, USA
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA
Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA
Department of Psychiatry, Division of Child and Adolescent Psychiatry, UCSF School of Medicine, UCSF, San Francisco, CA, USA
Department of Psychiatry, University of Pennsylvannia Perelman School of Medicine, Philadelphia, PA, USA
Department of Psychiatry, University of California San Diego, Los Angeles, CA, USA
Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare, San Diego, CA, USA
Department of Neuroscience, University of California San Diego, San Diego, CA, USA
Department of Psychiatry & Behavioral Sciences, Standord University, Stanford, CA, USA
Laureate Institute for Brain Research, Tulsa, OK, USA
Oxley College of Health Sciences, The University of Tulsa, Tulsa, OK, USA
Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain
FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Catalonia, Spain
Institut d'Investigació Biomèdica Sant Pau, Barcelona, Catalonia, Spain
Centro de Investigación Biomédica en Red de Salud Mental, Cibersam, Spain
Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33, Galway, Ireland
North Dublin Mental Health Services, Dublin, Ireland
UNIACT, Psychiatry Team, Neurospin, Atomic Energy Commission, Gif-Sur-Yvette, France
Translational Psychiatry Team, Pôle de psychiatrie, Faculté de Médecine, APHP, Hôpitaux Universitaires Mondor, INSERM, U955, Créteil, France
Neuroscience Institute, University of Cape Town, Cape Town, South Africa
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Department of Clinical Neuroscience, University of Oslo, Oslo, Norway
Clinic for Psychiatry and Dependency, C-L psychiatry and Psychosomatic Unit, Oslo University Hospital, Oslo, Norway
Department of Psychiatry and Neurology, CHU Grenoble Alpes, Université Grenoble Alpes, F-38000, Grenoble, France
Inserm 1216, Grenoble Institut des Neurosciences, GIN, F-38000, Grenoble, France
Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands
Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands
West Region and Research Division, Institute of Mental Health, Singapore, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Valkenberg Psychiatric Hospital, Cape Town, South Africa
Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, Sao Paulo, SP, Brazil
Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands
Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK
Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK
Division of Psychiatry, University of Edinburgh, Edinburgh, UK
Department of Psychiatry, University of Oxford, Oxford, UK
School of Psychology, University of East London, London, UK
Dementia Research Centre, Institute of Neurology, University College London, London, UK
MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK
Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia
FSSBI "Scientific Research Institute of Physiology & Basic Medicine", Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany
Department of Psychiatry, Philipps-University Marburg, Marburg, Germany
Section for Experimental Psychopathology and Neuroimaging, Department of Psychiatry, University of Heidelberg, Heidelberg, Germany
Department of Psychiatry, University of Calgary, Calgary, AB, Canada
Laboratory of Experimental & Translational Neuroscience, Novosibirsk State University, Novosibirsk, Russia
Max Planck Institute of Psychiatry, Munich, Germany
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands
Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada
Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Department of Psychiatry, University of Münster, Münster, Germany
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Clinic for Mental Health and Dependency, C-L psychiatry and Psychosomatic Unit, Oslo University Hospital, Oslo, Norway
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
Université de Paris, Service Hospitalo-Universitaire, GHU Paris Psychiatrie & Neuroscience, F-75014, Paris, France
Department of Clinical Neuroscience, Osher Center, Karolinska Institutet, Stockholm, Sweden
Instituto de Radiologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
Department of Psychiatry, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands
Laboratory of Psychiatric Neuroimaging (LIM-21), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
Department of Psychiatry, School of Medicine, University of Sao Paulo (FMUSP), Sao Paulo, Brazil
Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa
Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit & GGZinGeest, Amsterdam, The Netherlands
Issue Date: Sep-2021
Date: 2020-05-18
Publication information: Molecular Psychiatry 2021; 26(9): 5124-5139
Abstract: Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.
URI: https://ahro.austin.org.au/austinjspui/handle/1/28794
DOI: 10.1038/s41380-020-0754-0
ORCID: 0000-0001-9647-3723
0000-0002-7783-8798
0000-0002-5146-0096
0000-0003-1431-3852
0000-0002-7603-6152
0000-0003-3684-4208
0000-0002-9149-8726
0000-0002-0198-4588
0000-0002-6357-615X
0000-0003-2429-0391
0000-0002-4961-296X
0000-0001-7218-7810
0000-0003-2885-5898
0000-0002-9260-5490
0000-0002-9403-6121
0000-0002-4505-8869
0000-0003-4383-5043
0000-0001-7133-4970
0000-0002-0540-8027
0000-0003-4506-0579
0000-0002-1680-8480
0000-0001-9544-3944
0000-0002-9546-2763
0000-0001-7378-3411
0000-0002-8490-6891
0000-0002-8390-2709
0000-0003-4014-4490
0000-0002-9006-8863
0000-0003-3166-5606
0000-0002-4830-1190
0000-0002-9881-2511
0000-0003-1661-5192
0000-0001-9448-7769
0000-0001-7072-9399
0000-0003-2967-9662
0000-0001-9384-5587
0000-0002-9293-3128
0000-0003-4401-8950
0000-0003-1908-5588
0000-0001-6548-426X
Journal: Molecular Psychiatry
PubMed URL: 32424236
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/32424236/
Type: Journal Article
Appears in Collections:Journal articles

Show full item record

Page view(s)

2
checked on Apr 20, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.