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https://ahro.austin.org.au/austinjspui/handle/1/28794| Title: | Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group. | Austin Authors: | Han, Laura K M;Dinga, Richard;Hahn, Tim;Ching, Christopher R K;Eyler, Lisa T;Aftanas, Lyubomir;Aghajani, Moji;Aleman, André;Baune, Bernhard T;Berger, Klaus;Brak, Ivan;Filho, Geraldo Busatto;Carballedo, Angela;Connolly, Colm G;Couvy-Duchesne, Baptiste;Cullen, Kathryn R;Dannlowski, Udo;Davey, Christopher G;Dima, Danai;Duran, Fabio L S;Enneking, Verena;Filimonova, Elena;Frenzel, Stefan;Frodl, Thomas;Fu, Cynthia H Y;Godlewska, Beata R;Gotlib, Ian H;Grabe, Hans J;Groenewold, Nynke A;Grotegerd, Dominik;Gruber, Oliver;Hall, Geoffrey B;Harrison, Ben J;Hatton, Sean N;Hermesdorf, Marco;Hickie, Ian B;Ho, Tiffany C;Hosten, Norbert;Jansen, Andreas;Kähler, Claas;Kircher, Tilo;Klimes-Dougan, Bonnie;Krämer, Bernd;Krug, Axel;Lagopoulos, Jim;Leenings, Ramona;MacMaster, Frank P;MacQueen, Glenda;McIntosh, Andrew;McLellan, Quinn;McMahon, Katie L;Medland, Sarah E;Mueller, Bryon A;Mwangi, Benson;Osipov, Evgeny;Portella, Maria J;Pozzi, Elena;Reneman, Liesbeth;Repple, Jonathan;Rosa, Pedro G P;Sacchet, Matthew D;Sämann, Philipp G;Schnell, Knut;Schrantee, Anouk;Simulionyte, Egle;Soares, Jair C;Sommer, Jens;Stein, Dan J;Steinsträter, Olaf;Strike, Lachlan T;Thomopoulos, Sophia I;van Tol, Marie-José;Veer, Ilya M;Vermeiren, Robert R J M;Walter, Henrik;van der Wee, Nic J A;van der Werff, Steven J A;Whalley, Heather;Winter, Nils R;Wittfeld, Katharina;Wright, Margaret J;Wu, Mon-Ju;Völzke, Henry;Yang, Tony T;Zannias, Vasileios;de Zubicaray, Greig I;Zunta-Soares, Giovana B;Abé, Christoph;Alda, Martin;Andreassen, Ole A;Bøen, Erlend;Bonnin, Caterina M;Canales-Rodriguez, Erick J;Cannon, Dara;Caseras, Xavier;Chaim-Avancini, Tiffany M;Elvsåshagen, Torbjørn;Favre, Pauline;Foley, Sonya F;Fullerton, Janice M;Goikolea, Jose M;Haarman, Bartholomeus C M;Hajek, Tomas;Henry, Chantal;Houenou, Josselin;Howells, Fleur M;Ingvar, Martin;Kuplicki, Rayus;Lafer, Beny;Landén, Mikael;Machado-Vieira, Rodrigo;Malt, Ulrik F;McDonald, Colm;Mitchell, Philip B;Nabulsi, Leila;Otaduy, Maria Concepcion Garcia;Overs, Bronwyn J;Polosan, Mircea;Pomarol-Clotet, Edith;Radua, Joaquim;Rive, Maria M;Roberts, Gloria;Ruhe, Henricus G;Salvador, Raymond;Sarró, Salvador;Satterthwaite, Theodore D;Savitz, Jonathan;Schene, Aart H;Schofield, Peter R;Serpa, Mauricio H;Sim, Kang;Soeiro-de-Souza, Marcio Gerhardt;Sutherland, Ashley N;Temmingh, Henk S;Timmons, Garrett M;Uhlmann, Anne;Vieta, Eduard;Wolf, Daniel H;Zanetti, Marcus V;Jahanshad, Neda;Thompson, Paul M;Veltman, Dick J;Penninx, Brenda W J H;Marquand, Andre F;Cole, James H;Schmaal, Lianne | Affiliation: | The Florey Institute of Neuroscience and Mental Health Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia Sunshine Coast Mind and Neuroscience Institute, University of the Sunshine Coast QLD, Sippy Downs, QLD, Australia Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, VIC, Australia Youth Mental Health Team, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia QIMR Berghofer Medical Research Instititute, Brisbane, QLD, Australia Neuroscience Research Australia, Randwick, Sydney, NSW, Australia School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia School of Psychiatry, University of New South Wales, Kingsford, Sydney, NSW, Australia Black Dog Institute, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway Department of Neurology, Oslo University Hospital, Oslo, Norway Department of Neuroscience, Novosibirsk State University, Novosibirsk, Russia Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands Department of Psychology, School of Arts and Social Sciences, City, University of London, London, UK Department for Psychiatry, Trinity College Dublin, Dublin, Ireland Department of Psychiatry and Psychotherapy, Otto von Guericke University (OVGU), Magdeburg, Germany German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany Centre for Affective Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK German Center of Neurodegenerative Diseases (DZNE) Site Rostock/Greifswald, Greifswald, Germany Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany Departments of Psychiatry and Pediatrics, University of Calgary, Calgary, AB, Canada Addictions and Mental Health Strategic Clinical Network, Calgary, AB, Canada Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany Department of Psychiatry and Psychotherapy, Asklepios Fachklinikum Göttingen, Göttingen, Germany SA MRC Unit on Risk and Resilience, University of Cape Town, Cape Town, South Africa Department of Child Psychiatry, University Medical Center, Leiden, The Netherlands Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota, USA Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA Department of Psychology, Stanford University, Stanford, CA, USA Department of Psychology, University of Minnesota, Minneapolis, MN, USA Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA Department of Psychiatry, Division of Child and Adolescent Psychiatry, UCSF School of Medicine, UCSF, San Francisco, CA, USA Department of Psychiatry, University of Pennsylvannia Perelman School of Medicine, Philadelphia, PA, USA Department of Psychiatry, University of California San Diego, Los Angeles, CA, USA Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare, San Diego, CA, USA Department of Neuroscience, University of California San Diego, San Diego, CA, USA Department of Psychiatry & Behavioral Sciences, Standord University, Stanford, CA, USA Laureate Institute for Brain Research, Tulsa, OK, USA Oxley College of Health Sciences, The University of Tulsa, Tulsa, OK, USA Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Catalonia, Spain Institut d'Investigació Biomèdica Sant Pau, Barcelona, Catalonia, Spain Centro de Investigación Biomédica en Red de Salud Mental, Cibersam, Spain Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33, Galway, Ireland North Dublin Mental Health Services, Dublin, Ireland UNIACT, Psychiatry Team, Neurospin, Atomic Energy Commission, Gif-Sur-Yvette, France Translational Psychiatry Team, Pôle de psychiatrie, Faculté de Médecine, APHP, Hôpitaux Universitaires Mondor, INSERM, U955, Créteil, France Neuroscience Institute, University of Cape Town, Cape Town, South Africa Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Department of Clinical Neuroscience, University of Oslo, Oslo, Norway Clinic for Psychiatry and Dependency, C-L psychiatry and Psychosomatic Unit, Oslo University Hospital, Oslo, Norway Department of Psychiatry and Neurology, CHU Grenoble Alpes, Université Grenoble Alpes, F-38000, Grenoble, France Inserm 1216, Grenoble Institut des Neurosciences, GIN, F-38000, Grenoble, France Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands West Region and Research Division, Institute of Mental Health, Singapore, Singapore Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Valkenberg Psychiatric Hospital, Cape Town, South Africa Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, Sao Paulo, SP, Brazil Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK Division of Psychiatry, University of Edinburgh, Edinburgh, UK Department of Psychiatry, University of Oxford, Oxford, UK School of Psychology, University of East London, London, UK Dementia Research Centre, Institute of Neurology, University College London, London, UK MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia FSSBI "Scientific Research Institute of Physiology & Basic Medicine", Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany Department of Psychiatry, Philipps-University Marburg, Marburg, Germany Section for Experimental Psychopathology and Neuroimaging, Department of Psychiatry, University of Heidelberg, Heidelberg, Germany Department of Psychiatry, University of Calgary, Calgary, AB, Canada Laboratory of Experimental & Translational Neuroscience, Novosibirsk State University, Novosibirsk, Russia Max Planck Institute of Psychiatry, Munich, Germany Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany Department of Psychiatry, University of Münster, Münster, Germany Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany Clinic for Mental Health and Dependency, C-L psychiatry and Psychosomatic Unit, Oslo University Hospital, Oslo, Norway Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Psychiatry, Dalhousie University, Halifax, NS, Canada Université de Paris, Service Hospitalo-Universitaire, GHU Paris Psychiatrie & Neuroscience, F-75014, Paris, France Department of Clinical Neuroscience, Osher Center, Karolinska Institutet, Stockholm, Sweden Instituto de Radiologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil Department of Psychiatry, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands Laboratory of Psychiatric Neuroimaging (LIM-21), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil Department of Psychiatry, School of Medicine, University of Sao Paulo (FMUSP), Sao Paulo, Brazil Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit & GGZinGeest, Amsterdam, The Netherlands |
Issue Date: | Sep-2021 | Date: | 2020-05-18 | Publication information: | Molecular Psychiatry 2021; 26(9): 5124-5139 | Abstract: | Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/28794 | DOI: | 10.1038/s41380-020-0754-0 | ORCID: | 0000-0001-9647-3723 0000-0002-7783-8798 0000-0002-5146-0096 0000-0003-1431-3852 0000-0002-7603-6152 0000-0003-3684-4208 0000-0002-9149-8726 0000-0002-0198-4588 0000-0002-6357-615X 0000-0003-2429-0391 0000-0002-4961-296X 0000-0001-7218-7810 0000-0003-2885-5898 0000-0002-9260-5490 0000-0002-9403-6121 0000-0002-4505-8869 0000-0003-4383-5043 0000-0001-7133-4970 0000-0002-0540-8027 0000-0003-4506-0579 0000-0002-1680-8480 0000-0001-9544-3944 0000-0002-9546-2763 0000-0001-7378-3411 0000-0002-8490-6891 0000-0002-8390-2709 0000-0003-4014-4490 0000-0002-9006-8863 0000-0003-3166-5606 0000-0002-4830-1190 0000-0002-9881-2511 0000-0003-1661-5192 0000-0001-9448-7769 0000-0001-7072-9399 0000-0003-2967-9662 0000-0001-9384-5587 0000-0002-9293-3128 0000-0003-4401-8950 0000-0003-1908-5588 0000-0001-6548-426X |
Journal: | Molecular Psychiatry | PubMed URL: | 32424236 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/32424236/ | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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