Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28485
Title: Consensus guidelines for the diagnosis and management of invasive fungal disease due to moulds other than Aspergillus in the haematology/oncology setting, 2021.
Austin Authors: Bupha-Intr, Olivia;Butters, Coen;Reynolds, Gemma;Kennedy, Karina;Meyer, Wieland;Patil, Sushrut;Bryant, Penelope;Morrissey, Catherine O
Affiliation: Infectious Diseases..
Malignant Haematology and Stem Cell Transplantation Service, Department of Clinical Haematology, The Alfred Hospital, Melbourne, Victoria, Australia..
Department of Infectious Diseases, The Royal Children's Hospital, Melbourne, Victoria, Australia..
Department of Infection Services, Wellington Regional Hospital, Wellington, New Zealand..
Westmead Institute for Medical Research, Sydney, New South Wales, Australia..
Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, New South Wales, Australia..
Research and Education Network, Westmead Hospital, Sydney, New South Wales, Australia..
Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Westmead Clinical School and Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australian National University, Canberra, Australia..
Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia..
ANU Medical School, Australian Capital Territory, Australia..
Department of Infectious Diseases and Microbiology, Canberra Hospital and Health Services, Canberra, Australia..
Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia..
Department of General Paediatric and Adolescent Medicine, John Hunter Children's Hospital, Newcastle, New South Wales, Australia..
Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria, Australia..
Department of Infectious Diseases, The Alfred Hospital, Melbourne, Victoria, Australia..
Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Victoria, Australia..
Issue Date: Nov-2021
Publication information: Internal medicine journal 2021; 51 Suppl 7: 177-219
Abstract: Invasive fungal disease (IFD) due to moulds other than Aspergillus is a significant cause of mortality in patients with malignancies or post haemopoietic stem cell transplantation. The current guidelines focus on the diagnosis and management of the common non-Aspergillus moulds (NAM), such as Mucorales, Scedosporium species (spp.), Lomentospora prolificans and Fusarium spp. Rare but emerging NAM including Paecilomyces variotii, Purpureocillium lilacinum and Scopulariopsis spp. are also reviewed. Culture and histological examination of tissue biopsy specimens remain the mainstay of diagnosis, but molecular methods are increasingly being used. As NAM frequently disseminate, blood cultures and skin examination with biopsy of any suspicious lesions are critically important. Treatment requires a multidisciplinary approach with surgical debridement as a central component. Other management strategies include control of the underlying disease/predisposing factors, augmentation of the host response and the reduction of immunosuppression. Carefully selected antifungal therapy, guided by susceptibility testing, is critical to cure. We also outline novel antifungal agents still in clinical trial which offer substantial potential for improved outcomes in the future. Paediatric recommendations follow those of adults. Ongoing epidemiological research, improvement in diagnostics and the development of new antifungal agents will continue to improve the poor outcomes that have been traditionally associated with IFD due to NAM.
URI: https://ahro.austin.org.au/austinjspui/handle/1/28485
DOI: 10.1111/imj.15592
ORCID: 0000-0002-9561-3592
Journal: Internal medicine journal
PubMed URL: 34937139
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/34937139/
Type: Journal Article
Subjects: Lomentospora prolificans
fusariosis
invasive mould disease
mucormycosis
non-Aspergillus mould
scedosporiosis
Appears in Collections:Journal articles

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