Please use this identifier to cite or link to this item:
Title: A Survey on Knowledge Gaps in Assessment and Management of Severe Drug Hypersensitivity Reactions: Multicenter Cross-Sectional Study of Australian Health Care Providers.
Austin Authors: Mazzoni, Daniel;Tee, Hui Wen;de Menezes, Sara Lee;Graudins, Linda Velta;Johnson, Douglas Forsyth;Newnham, Evan David;Kelley, Peter Graham;Zubrinich, Celia Mary;Goh, Michelle Sue Yen;Trubiano, Jason Anthony;Aung, Ar Kar
Affiliation: General Medicine
Infectious Diseases
Department of Allergy, Immunology and Respiratory Medicine, Alfred Health, Melbourne, Victoria, Australia
Department of Infectious Diseases, Peninsula Health, Melbourne, Victoria, Australia
Department of General Medicine, Eastern Health, Melbourne, Victoria, Australia
The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Department of General Medicine and Infectious Diseases, The Royal Melbourne Hospital, Melbourne, Victoria, Australia
Pharmacy Department, Alfred Health, Melbourne, Victoria, Australia
Department of General Medicine, Alfred Health, Melbourne, Victoria, Australia
Department of Dermatology, Alfred Health, Melbourne, Victoria, Australia
Issue Date: Jan-2021
Date: 2020-07-10
Publication information: Journal of Clinical Pharmacology 2021; 61(1): 25-31
Abstract: Severe drug hypersensitivity reactions (DHRs) are often encountered by health care professionals (HCPs). We evaluated knowledge of doctors and pharmacists in the assessment and management of severe DHRs using a structured questionnaire. A cross-sectional study was conducted in 4 metropolitan hospital networks in Melbourne, Australia. A 13-question, scenario-based multiple-choice questionnaire to assess specific knowledge domains in drug hypersensitivity syndrome recognition, causality attribution, cross-reactivity patterns, appropriate diagnostic tests, and therapy was administered to HCPs of various vocation and specialty groups. Data were analyzed according to profession, self-reported experience, and preparedness in managing severe DHRs. Two hundred thirty-eight participants (45.0% senior doctors, 24.4% junior doctors, and 30.7% pharmacists) across a range of subspecialties achieved an overall median score of 7 (IQR, 5-8)-overall 55.6% correct responses to all questions-with senior doctors outperforming junior doctors and pharmacists (P < .001). The best performance by all participants was in DHR syndrome recognition (60.9%), and the poorest was in diagnostics/therapy (52.0%). HCP group and experience level were significantly associated with better performance in the knowledge domains of cross-reactivity and diagnostics/therapy (P = .003 and < .001, respectively), but not in the domains of syndrome recognition and causality attribution (P > .05). Levels of self-reported preparedness in DHR management were not associated with performance rates in any of the knowledge domains. This study demonstrated significant knowledge gaps in the recognition and management of severe drug hypersensitivity reactions. Targeted multidisciplinary education of staff caring for these patients is needed to improve knowledge gaps.
DOI: 10.1002/jcph.1692
ORCID: 0000-0003-3317-945X
Journal: Journal of Clinical Pharmacology
PubMed URL: 32648298
PubMed URL:
Type: Journal Article
Subjects: adverse drug reaction
drug hypersensitivity
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Dec 1, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.