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dc.contributor.authorMazzoni, Daniel-
dc.contributor.authorTee, Hui Wen-
dc.contributor.authorde Menezes, Sara Lee-
dc.contributor.authorGraudins, Linda Velta-
dc.contributor.authorJohnson, Douglas Forsyth-
dc.contributor.authorNewnham, Evan David-
dc.contributor.authorKelley, Peter Graham-
dc.contributor.authorZubrinich, Celia Mary-
dc.contributor.authorGoh, Michelle Sue Yen-
dc.contributor.authorTrubiano, Jason Anthony-
dc.contributor.authorAung, Ar Kar-
dc.identifier.citationJournal of Clinical Pharmacology 2021; 61(1): 25-31en
dc.description.abstractSevere drug hypersensitivity reactions (DHRs) are often encountered by health care professionals (HCPs). We evaluated knowledge of doctors and pharmacists in the assessment and management of severe DHRs using a structured questionnaire. A cross-sectional study was conducted in 4 metropolitan hospital networks in Melbourne, Australia. A 13-question, scenario-based multiple-choice questionnaire to assess specific knowledge domains in drug hypersensitivity syndrome recognition, causality attribution, cross-reactivity patterns, appropriate diagnostic tests, and therapy was administered to HCPs of various vocation and specialty groups. Data were analyzed according to profession, self-reported experience, and preparedness in managing severe DHRs. Two hundred thirty-eight participants (45.0% senior doctors, 24.4% junior doctors, and 30.7% pharmacists) across a range of subspecialties achieved an overall median score of 7 (IQR, 5-8)-overall 55.6% correct responses to all questions-with senior doctors outperforming junior doctors and pharmacists (P < .001). The best performance by all participants was in DHR syndrome recognition (60.9%), and the poorest was in diagnostics/therapy (52.0%). HCP group and experience level were significantly associated with better performance in the knowledge domains of cross-reactivity and diagnostics/therapy (P = .003 and < .001, respectively), but not in the domains of syndrome recognition and causality attribution (P > .05). Levels of self-reported preparedness in DHR management were not associated with performance rates in any of the knowledge domains. This study demonstrated significant knowledge gaps in the recognition and management of severe drug hypersensitivity reactions. Targeted multidisciplinary education of staff caring for these patients is needed to improve knowledge gaps.en
dc.subjectadverse drug reactionen
dc.subjectdrug hypersensitivityen
dc.titleA Survey on Knowledge Gaps in Assessment and Management of Severe Drug Hypersensitivity Reactions: Multicenter Cross-Sectional Study of Australian Health Care Providers.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Clinical Pharmacologyen
dc.identifier.affiliationGeneral Medicineen
dc.identifier.affiliationInfectious Diseasesen
dc.identifier.affiliationDepartment of Allergy, Immunology and Respiratory Medicine, Alfred Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Infectious Diseases, Peninsula Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of General Medicine, Eastern Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationThe National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australiaen
dc.identifier.affiliationSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of General Medicine and Infectious Diseases, The Royal Melbourne Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationPharmacy Department, Alfred Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of General Medicine, Alfred Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Dermatology, Alfred Health, Melbourne, Victoria, Australiaen
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item.openairetypeJournal Article-
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