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Title: | Current State of Neoadjuvant Radiotherapy for Rectal Cancer. | Austin Authors: | Ng, Sweet Ping ;Ngan, Samuel Y;Leong, Trevor | Affiliation: | Department of Surgery, The University of Melbourne, Melbourne, Australia Radiation Oncology School of Molecular Sciences, La Trobe University, Melbourne, Australia Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia Olivia Newton-John Cancer Wellness and Research Centre |
Issue Date: | 2022 | Date: | 2021-11-04 | Publication information: | Clinical Colorectal Cancer 2022; 21(1): 63-70 | Abstract: | Colorectal cancer is the third most commonly diagnosed cancer, with rectal cancer accounting for 30% of cases. The current standard of care curative treatment for locally advanced rectal cancer is (chemo)radiotherapy followed by surgery and adjuvant chemotherapy. Although neoadjuvant radiotherapy has reduced the risk of local recurrence to less than 10%, the risk of distant metastasis remained high at 30% affecting patient survival. In addition, there is a recognition that there is heterogeneity in tumor biology and treatment response with good responders potentially suitable for treatment de-escalation. Therefore, new treatment sequencing and regimens were investigated. Here, we reviewed the evidence for current neoadjuvant treatment options in patients with locally advanced rectal adenocarcinoma, and highlight the new challenges in this new treatment landscape. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/28299 | DOI: | 10.1016/j.clcc.2021.10.008 | Journal: | Clinical Colorectal Cancer | PubMed URL: | 34852972 | Type: | Journal Article | Subjects: | Biomarker Chemoradiotherapy Locally advanced Short course Surgery |
Appears in Collections: | Journal articles |
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