Please use this identifier to cite or link to this item:
Title: Recent Research on Combination of Radiotherapy with Targeted Therapy or Immunotherapy in Head and Neck Squamous Cell Carcinoma: A Review for Radiation Oncologists.
Austin Authors: Xing, Daniel T ;Khor, Richard ;Gan, Hui K ;Wada, Morikatsu ;Ermongkonchai, Tai;Ng, Sweet Ping 
Affiliation: Faculty of Medicine, Dentistry and Health Science, University of Melbourne, Melbourne, VIC 3000, Australia
Olivia Newton-John Cancer Wellness and Research Centre
Medical Oncology
La Trobe University School of Cancer Medicine, Heidelberg, VIC 3079, Australia
Department of Medicine, University of Melbourne, Melbourne, VIC 3000, Australia
Issue Date: 15-Nov-2021 2021
Publication information: Cancers 2021; 13(22): 5716
Abstract: Radiotherapy plays an important role of managing head and neck squamous cell carcinoma (HNSCC). Concurrent radiotherapy with radiosensitizing cisplastin chemotherapy is the standard of care (SOC) for non-operable locally advanced HNSCC. Cetuximab, a monoclonal antibody of epidermal growth factor receptor, was the most extensively studied targeted therapy as a chemo-sparing agent that was used concurrently with radiotherapy. Immunotherapy is used in the treatment of metastatic HNSCC. There is evidence to support the synergistic effect when combining radiotherapy with immunotherapy to potentiate anti-tumor immune response. There has been increasing interest to incorporate immune checkpoint inhibitor (ICI) with radiotherapy in the curative setting for HNSCC. In this review, we discuss the latest evidence that supports concurrent radiotherapy with cisplatin which remains the SOC for locally advanced HNSCC (LA-HNSCC). Cetuximab is suitable for patients who are not fit for cisplatin. We then summarize the clinical trials that incorporate ICI with radiotherapy for LA-HNSCC in concurrent, neoadjuvant, and adjuvant settings. We also discuss the potential of combining immunotherapy with radiotherapy as a treatment de-escalating strategy in HPV-associated oropharyngeal carcinoma. Finally, the pre-clinical and clinical evidence of the abscopal effect when combining stereotactic body radiotherapy with ICIs is presented.
DOI: 10.3390/cancers13225716
ORCID: 0000-0002-2210-5773
Journal: Cancers
PubMed URL: 34830871
ISSN: 2072-6694
Type: Journal Article
Subjects: abscopal effect
epidermal growth factor receptor
stereotactic body radiotherapy
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Jun 9, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.