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Title: Physiological responses during downhill walking: A new exercise modality for subjects with chronic obstructive pulmonary disease?
Austin Authors: Camillo, Carlos Augusto;Burtin, Chris;Hornikx, Miek;Demeyer, Heleen;De Bent, Kristien;van Remoortel, Hans;Osadnik, Christian R;Janssens, Wim;Troosters, Thierry
Affiliation: Institute for Breathing and Sleep
Monash University, Department of Physiotherapy, Victoria, Australia
KU Leuven, Department of Rehabilitation Sciences, Leuven, Belgium
Hasselt University, Rehabilitation Research Centre, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Diepenbeek, Belgium
University Hospital Leuven, Respiratory Division and Rehabilitation, Leuven, Belgium
Issue Date: May-2015 2015-03-10
Publication information: Chronic Respiratory Disease 2015; 12(2): 155-64
Abstract: Skeletal muscle quadriceps low-frequency fatigue (LFF) during exercise promotes improvements in exercise capacity with exercise training. In healthy subjects, eccentric muscle work induced by downhill walking (DW) generates higher muscular stress, whilst metabolic cost is lower compared to level walking (LW). We investigated quadriceps LFF and metabolic cost of DW in patients with chronic obstructive pulmonary disease. Ten participants (67 ± 7 years, FEV1 51 ± 15% predicted) performed DW, DW carrying a load (DWL) of 10% body weight via vest and LW, in random order. Quadriceps potentiated twitch force (TWqpot) was assessed before and after each walk, and muscle damage was assessed before and 24 hours after each walk via serum creatine kinase (CK) levels. Ventilation (VE) and oxygen consumption (VO2) were measured via breath-by-breath analysis during each walk. DW and DWL resulted in a greater decrease in TWqpot (-30 ± 14 N in DW, p < 0.05; and -22 ± 16 N in DWL, p < 0.05) compared to LW (-3 ± 21 N, p > 0.05). CK levels only increased 24 hours following DW and DWL (p < 0.05). DW and DWL showed lower VE and VO2 than LW (p < 0.05). DW is associated with enhanced quadriceps LFF and lower cardiorespiratory costs than LW. The addition of a chest load to DW does not seem to enhance these effects.
DOI: 10.1177/1479972315575717
ORCID: 0000-0001-9040-8007
Journal: Chronic Respiratory Disease
PubMed URL: 25758676
PubMed URL:
Type: Journal Article
Subjects: Pulmonary disease
cardiorespiratory costs
chronic obstructive
downhill walking
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