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Title: Airways resistance and specific conductance for the diagnosis of obstructive airways diseases.
Austin Authors: Topalovic, Marko;Derom, Eric;Osadnik, Christian R;Troosters, Thierry;Decramer, Marc;Janssens, Wim
Affiliation: Institute for Breathing and Sleep
Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Leuven, Belgium
Respiratory Division, University Hospital Ghent, University of Ghent, Ghent, Belgium..
Department of Physiotherapy, Monash University, Victoria, Australia
Department of Clinical and Experimental Medicine, Laboratory of Respiratory Diseases, University Hospital Leuven, KULEUVEN University of Leuven, Herestraat 49, 3000, Leuven, Belgium
Monash Health, Monash Lung and Sleep, Victoria, Australia
Issue Date: 22-Jul-2015
Date: 2015
Publication information: Respiratory research 2015; 16(1): 88.
Abstract: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). RAW and sGAW were significantly different (pā€‰<ā€‰0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.
DOI: 10.1186/s12931-015-0252-0
ORCID: 0000-0001-9040-8007
Journal: Respiratory research
PubMed URL: 26194099
PubMed URL:
Type: Journal Article
Appears in Collections:Journal articles

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