Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28193
Title: Deterioration in physical activity and function differs according to treatment type in non-small cell lung cancer - future directions for physiotherapy management.
Austin Authors: Granger, Catherine L ;Parry, S M;Edbrooke, L;Denehy, L
Affiliation: Institute for Breathing and Sleep
Department of Physiotherapy, Royal Melbourne Hospital, Grattan Street, Parkville 3010, Victoria, Australia
Department of Physiotherapy, The University of Melbourne, 161 Barry Street, Parkville 3010, Victoria, Australia
Issue Date: Sep-2016
Date: 2015-10-23
Publication information: Physiotherapy 2016; 102(3): 256-263.
Abstract: To investigate in non-surgically and surgically treated non-small cell lung cancer (NSCLC): (1) changes in physical activity, function, health-related quality of life (HRQoL) and symptoms after diagnosis; and (2) the association between physical activity and outcomes. Prospective observational study. Three acute tertiary hospitals. Sixty-nine individuals (43 male, median [IQR] age 68 [61 to 74] years) with stage I-IV NSCLC. The primary outcome (Physical Activity Scale for the Elderly) and secondary outcome (six-minute walk test and questionnaires assessing HRQoL, function, symptoms, mood) were measured at diagnosis (pre-treatment), and eight to ten weeks post-diagnosis (post-operative and/or during chemotherapy/radiotherapy). Individuals treated surgically (n=27) experienced a deterioration in physical activity levels (baseline median [IQR]=74 [51 to 135]; follow-up median [IQR]=29 [24 to 73]; median difference=45, effect size=0.3). At follow-up physical activity was inversely related to depression, pain and appetite loss (rho>0.5, p<0.05). In contrast non-surgical individuals (n=42) did not experience a change in physical activity, however did experience deterioration in function, functional capacity, global HRQoL, fatigue and dyspnoea. Physical activity levels were low in this group and at follow-up the strongest relationships with physical activity levels were global HRQoL, function, fatigue and mood (inverse, rho>0.5, p<0.05). Surgically treated individuals experienced a reduction in physical activity levels after diagnosis, which was not seen in the non-surgical group. Lower physical activity levels were associated with poorer outcomes, particularly in non-surgically treated individuals. Further research is required to establish the optimal intervention to improve physical activity levels in these cohorts.
URI: https://ahro.austin.org.au/austinjspui/handle/1/28193
DOI: 10.1016/j.physio.2015.10.007
ORCID: 0000-0001-6169-370X
Journal: Physiotherapy
PubMed URL: 26597694
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/26597694/
Type: Journal Article
Subjects: Function
Health-related quality of life
Lung neoplasms
Non-small cell lung cancer
Physical activity
Physiotherapy
Appears in Collections:Journal articles

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