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Title: Curative Radiotherapy for Locally Advanced Scalp Squamous Cell Carcinoma.
Austin Authors: Xing, Daniel T ;Hettige, Supan;Chee, Lessandra Yan Shan;Nair, Rohan;Hegde, Rajendra
Affiliation: Radiation Oncology, William Buckland Radiotherapy Centre, The Alfred Health, Melbourne, AUS
Radiation Oncology
Gippsland Radiation Oncology, Latrobe Regional Hospital, Traralgon, AUS
Olivia Newton-John Cancer Wellness and Research Centre
Issue Date: 5-Oct-2021
Date: 2021-10
Publication information: Cureus 2021; 13(10): e18514
Abstract: A 73-year-old man presented to his primary physician with an ulcerative growth on his scalp vertex. Biopsy of the lesion confirmed the growth to be a moderately differentiated squamous cell carcinoma, but the patient declined medical intervention. The lesion increased in size over six months, measuring 12 cm in diameter and 3 cm thickness with erosion of the skull of the vertex. CT and MRI scans showed a large fungating mass with erosion of the skull of vertex without intra-cranial extension, meningeal enhancement, or distant metastatic disease. The patient declined surgical intervention. The patient received radiotherapy using volumetric-modulated arc therapy (VMAT) to a total dose of 60 Gy over six weeks. No evidence of clinical invasive disease apart from a 15 cm * 12 cm skin defect detected three months after completion of radiotherapy. At three years of follow-up, the patient is clinically disease-free. This case report provides evidence that high-dose radiotherapy is a potential effective definitive treatment for locally advanced (T4) squamous cell carcinoma for patients who are unwilling to undergo surgery.
DOI: 10.7759/cureus.18514
Journal: Cureus
PubMed URL: 34754673
PubMed URL: 34754673
ISSN: 2168-8184
Type: Journal Article
Subjects: cutaneous squamous cell carcinoma
external beam radiation
head and neck cancer
volumetric-modulated arc therapy
Appears in Collections:Journal articles

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