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Title: High intensity interval training versus moderate intensity continuous training for people with interstitial lung disease: protocol for a randomised controlled trial.
Austin Authors: Dowman, Leona M ;May, Anthony K;Hill, Catherine J ;Bondarenko, Janet;Spencer, Lissa;Morris, Norman R;Alison, Jennifer A;Walsh, James;Goh, Nicole S L ;Corte, Tamera;Glaspole, Ian;Chambers, Daniel C;McDonald, Christine F ;Holland, Anne E 
Affiliation: Faculty of Medicine and Health Science, Sydney School of Health Sciences, University of Sydney, Sydney, NSW, Australia
School of Health Sciences and Social Work, The Hopkins Centre, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia
Metro North Hospital and Health Service, The Prince Charles Hospital, Allied Health Research Collaborative, Chermside, QLD, Australia
Allied Health Professorial Unit, Sydney Local Health District, Sydney, NSW, Australia
Respiratory Research @ Alfred, Central Clinical School, Monash University, Melbourne, VIC, Australia
Respiratory and Sleep Medicine
Institute for Breathing and Sleep
Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia
Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia
Department of Physiotherapy, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Department of Physiotherapy, Alfred Health, Melbourne, VIC, Australia
Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Central Clinical School, University of Sydney, Sydney, NSW, Australia
NHMRC Centre of Research Excellence in Pulmonary Fibrosis, Sydney, NSW, Australia
Department of Respiratory Medicine, Alfred Hospital, Melbourne, VIC, Australia
Central Clinical School, Monash University, Melbourne, VIC, Australia
School of Medicine, University of Queensland, Brisbane, QLD, Australia
Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, QLD, Australia
Issue Date: 10-Nov-2021
Date: 2021
Publication information: BMC pulmonary medicine 2021-11-10; 21(1): 361
Abstract: Interstitial lung disease is a debilitating condition associated with significant dyspnoea, fatigue, and poor exercise tolerance. Pulmonary rehabilitation is an effective and key intervention in people with interstitial lung disease. However, despite the best efforts of patients and clinicians, many of those who participate are not achieving clinically meaningful benefits. This assessor-blinded, multi-centre, randomised controlled trial aims to compare the clinical benefits of high intensity interval exercise training versus the standard pulmonary rehabilitation method of continuous training at moderate intensity in people with fibrotic interstitial lung disease. Eligible participants will be randomised to either a standard pulmonary rehabilitation group using moderate intensity continuous exercise training or high intensity interval exercise training. Participants in both groups will undertake an 8-week pulmonary rehabilitation program of twice-weekly supervised exercise training including aerobic (cycling) and strengthening exercises. In addition, participants in both groups will be prescribed a home exercise program. Outcomes will be assessed at baseline, upon completion of the intervention and at six months following the intervention by a blinded assessor. The primary outcome is endurance time on a constant work rate test. Secondary outcomes are functional capacity (6-min walk distance), health-related quality of life (Chronic Respiratory Disease Questionnaire (CRQ), St George's Respiratory Questionnaire idiopathic pulmonary fibrosis specific version (SGRQ-I), breathlessness (Dyspnoea 12, Modified Medical Research Council Dyspnoea Scale), fatigue (fatigue severity scale), anxiety (Hospital Anxiety and Depression Scale), physical activity level (GeneActiv), skeletal muscle changes (ultrasonography) and completion and adherence to pulmonary rehabilitation. The standard exercise training strategies used in pulmonary rehabilitation may not provide an optimal exercise training stimulus for people with interstitial lung disease. This study will determine whether high intensity interval training can produce equivalent or even superior changes in exercise performance and symptoms. If high intensity interval training proves effective, it will provide an exercise training strategy that can readily be implemented into clinical practice for people with interstitial lung disease. Trial registration Registry (NCT03800914). Registered 11 January 2019, Australian New Zealand Clinical Trials Registry ACTRN12619000019101. Registered 9 January 2019,
DOI: 10.1186/s12890-021-01704-2
ORCID: 0000-0001-8122-8063
Journal: BMC Pulmonary Medicine
PubMed URL: 34758808
PubMed URL:
Type: Journal Article
Subjects: Endurance training
High-Intensity interval training
Idiopathic pulmonary fibrosis
Interstitial lung diseases
Pulmonary Fibrosis
Appears in Collections:Journal articles

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