Austin Health

Title
Procurement-related liver injury for transplantation: an analysis of the risk factors and consequences in an Australian transplant centre.
Publication Date
2021-12
Author(s)
Walcott, James
Fink, Michael A
Ealing, Isaac
Christophi, Christopher
Muralidharan, Vijayaragavan
Subject
liver Injury
liver Transplant
transplant outcomes
Type of document
Journal Article
OrcId
0000-0001-9036-6804
0000-0001-8247-8937
DOI
10.1111/ans.17285
Abstract
Liver transplantation is an established treatment for liver failure, and its success relies on the quality of the donated organ amongst other factors. Studies on procurement-related liver injury (PRLI) are few and some may not apply to modern-day practice. This is the first Australian study examining risk factors and consequences of PRLI. The Victorian Liver Transplant Unit database was examined for deceased liver donors from 2010 to 2017. Information regarding the donor, retrieval and subsequent transplantation was obtained. PRLI details were sought from the 'organ retrieval report form'. PRLI risk factors and their complications were analysed. A total of 420 transplants were included, with 45 injuries in 44 livers (10%), and significant injuries were observed in 4%. Variant anatomy was associated with an increased risk of PRLI (11% vs. 2%, p < 0.001). Complication rates were not significantly different between livers with and without PRLI however a reduction in early graft survival was observed. This study shows that PRLI is common, and that variant anatomy is associated with an increased risk of injury. Appropriate feedback and benchmarking are important to maintain a high quality in donor surgery.
Link
Citation
ANZ journal of surgery 2021-12; 91(12): 2669-2674
Jornal Title
ANZ Journal of Surgery

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