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Title: Mortality Risk from Neurodegenerative Disease in Sports Associated with Repetitive Head Impacts: Preliminary Findings from a Systematic Review and Meta-Analysis.
Austin Authors: Morales, Javier S;Valenzuela, Pedro L;Saco-Ledo, Gonzalo;Castillo-García, Adrián;Carabias, Cristina S;McCrory, Paul;Santos-Lozano, Alejandro;Lucia, Alejandro
Affiliation: Traumatic Brain Injury Laboratory, The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre-Austin Campus, Heidelberg, VIC, Australia
MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cadiz, Spain
Physical Activity and Health Laboratory, Instituto de Investigación Sanitaria Hospital '12 de Octubre' ('imas12', PaHerg), Madrid, Spain
I+HeALTH, Department of Health Sciences, European University Miguel de Cervantes, Valladolid, Spain
Faculty of Sport Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, 28670, Madrid, Spain
Physical Activity and Health Laboratory, Instituto de Investigación Sanitaria Hospital '12 de Octubre' ('imas12', PaHerg), Madrid, Spain..
Bioenergy and Motion Analysis Laboratory, National Research Center on Human Evolution (CENIEH), Burgos, Spain..
Fissac-Physiology, Health and Physical Activity, Madrid, Spain
Neurotraumatology and Subarachnoid Hemorrhage Research Unit, Department of Neurosurgery, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain
Austin Health
Issue Date: 2022
Date: 2021-10-21
Publication information: Sports medicine (Auckland, N.Z.) 2022; 52(4): 835-846S
Abstract: Professional athletes seem to have a lower overall mortality risk than the general population, but controversy exists about whether athletes in sports associated with repetitive head impacts have a higher risk of mortality from neurodegenerative diseases. We aimed to determine the risk of mortality from neurodegenerative diseases in sports associated with repeated head impacts compared with the general population or compared with athletes with no such exposure. We conducted a systematic review with meta-analysis, systematically searching PubMed, Web of Science, Scopus, and SPORTDiscus (since inception to 14 May 2021) for studies comparing the risk of death from neurodegenerative disease in athletes participating in contact sports in which their heads recurrently receive blows from the bodies of other participants or from a ball versus a control group or dataset representing the general population. Six moderate- to high-quality retrospective studies including data from 41,699 athletes participating in contact sports (boxing, basketball, ice hockey, American Football and soccer) met all inclusion criteria to be included in the systematic review. Of these, three studies (N = 37,065 male professional soccer players) could be meta-analysed. Despite no differences in the risk of all-cause (p = 0.138), cardiovascular (p = 0.085) and cancer-related mortality (p = 0.136), soccer players presented with a significantly higher mortality risk from motor neuron disease (standard mortality rate 8.43; 95% confidence interval 3.07-23.13; p < 0.001). Although more research is needed (particularly in other contact sports and with neurodegenerative disease as the cause of death), preliminary evidence suggests that participation in professional soccer might increase the risk of mortality from motor neuron disease compared with the general population. The present findings highlight the need for the design of preventive measures and for adequate neuropsychological monitoring in these athletes. CRD42020195647.
DOI: 10.1007/s40279-021-01580-0
ORCID: 0000-0002-3255-3246
Journal: Sports Medicine
PubMed URL: 34674184
Type: Journal Article
Appears in Collections:Journal articles

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