Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/27756
Title: Outcomes Measured in Polymyalgia Rheumatica and Measurement Properties of Instruments Considered for the OMERACT Core Outcome Set: A Systematic Review.
Austin Authors: Twohig, Helen;Owen, Claire E ;Muller, Sara;Mallen, Christian D;Mitchell, Caroline;Hider, Samantha;Hill, Catherine J ;Shea, Beverley;Mackie, Sarah L
Affiliation: Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
Primary Care Centre Versus Arthritis, School of Primary, Community and Social Care, Keele University, Staffordshire, UK
Department of Medicine, University of Melbourne, Melbourne, Australia
Rheumatology Unit, The Queen Elizabeth and Royal Adelaide Hospitals, and Discipline of Medicine, The University of Adelaide, Adelaide, Australia
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Woodhouse, Leeds, UK
Academic Department of Primary Medical Care, University of Sheffield, Sheffield, UK
Rheumatology
Issue Date: Jun-2021
Date: 2020-08-01
Publication information: The Journal of Rheumatology 2021; 48(6): 883-893
Abstract: To systematically identify the outcome measures and instruments used in clinical studies of polymyalgia rheumatica (PMR) and to evaluate evidence about their measurement properties. Searches based on the MeSH term "polymyalgia rheumatica" were carried out in 5 databases. Two researchers were involved in screening, data extraction, and risk of bias assessment. Once outcomes and instruments used were identified and categorized, key instruments were selected for further review through a consensus process. Studies on measurement properties of these instruments were appraised against the COSMIN-OMERACT (COnsensus-based Standards for the selection of health Measurement Instruments-Outcome Measures in Rheumatology) checklist to determine the extent of evidence supporting their use in PMR. Forty-six studies were included. In decreasing order of frequency, the most common outcomes (and instruments) used were markers of systemic inflammation [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)], pain [visual analog scale (VAS)], stiffness (duration in minutes), and physical function (elevation of upper limbs). Instruments selected for further evaluation were ESR, CRP, pain VAS, morning stiffness duration, and the Health Assessment Questionnaire. Five studies evaluated measurement properties of these instruments, but none met all of the COSMIN-OMERACT checklist criteria. Measurement of outcomes in studies of PMR lacks consistency. The critical patient-centered domain of physical function is poorly assessed. None of the candidate instruments considered for inclusion in the core outcome set had high-quality evidence, derived from populations with PMR, on their full range of measurement properties. Further studies are needed to determine whether these instruments are suitable for inclusion in a core outcome measurement set for PMR.
URI: https://ahro.austin.org.au/austinjspui/handle/1/27756
DOI: 10.3899/jrheum.200248
ORCID: 0000-0001-8781-1268
0000-0002-2677-1028
0000-0002-4790-0095
0000-0003-2483-5873
Journal: The Journal of Rheumatology
PubMed URL: 32739892
ISSN: 0315-162X
Type: Journal Article
Subjects: OMERACT
outcome measures
polymyalgia rheumatica
systematic review
Appears in Collections:Journal articles

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