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Title: Osteoporosis in rheumatoid arthritis. A monozygotic co-twin control study.
Austin Authors: Sambrook, P N;Spector, T D;Seeman, E;Bellamy, N;Buchanan, Russell R C ;Duffy, D L;Martin, N G;Prince, R;Owen, E;Silman, A J
Affiliation: Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, Australia
Medicine (University of Melbourne)
Issue Date: Jun-1995
Publication information: Arthritis and Rheumatism 1995; 38(6): 806-9
Abstract: To quantify the magnitude and distribution of osteoporosis in rheumatoid arthritis (RA). Bone mineral density (BMD) was measured by dual x-ray absorptiometry, in a monozygotic co-twin control study. BMD was reduced at most skeletal sites in the twin with RA compared with the co-twin (lumbar spine 4.6%, femoral neck 9.7%, total body 5.7%). Differences in lean soft tissue (5.6% for total body) correlated with differences in BMD between twins at multiple sites. Osteoporosis in RA is generalized and may be related to loss of mobility or muscle mass associated with the disease.
DOI: 10.1002/art.1780380614
Journal: Arthritis and Rheumatism
PubMed URL: 7779124
ISSN: 0004-3591
Type: Journal Article
Appears in Collections:Journal articles

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