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https://ahro.austin.org.au/austinjspui/handle/1/27688| Title: | Lupus anticoagulant in the elderly may be associated with both quinine and quinidine usage. | Austin Authors: | Bird, M R;O'Neill, A I;Buchanan, Russell R C ;Ibrahim, K M;Des Parkin, J | Affiliation: | Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria | Issue Date: | Apr-1995 | Publication information: | Pathology 1995; 27(2): 136-9 | Abstract: | Thirty-one patients aged over 60 yrs and with lupus anticoagulant (LA) were reviewed for their drug intake. Twenty-three (73%) were taking cinchona alkaloids, 10 (32%) quinine for night cramps, 11 (35%) quinidine for cardiac arrhythmia and 2 (6%) were taking both. These frequencies of drugs usage differed significantly from age and sex matched controls (p < 0.001). Five patients had features suggestive of the antiphospholipid syndrome. Repeat testing showed persistent LA activity in all but 2 of 5 patients in whom the relevant drug had been ceased. This is the first description of a possible causal association between LA and quinine therapy. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/27688 | DOI: | 10.1080/00313029500169742 | Journal: | Pathology | PubMed URL: | 7567140 | ISSN: | 0031-3025 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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