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|Title:||Lupus anticoagulant in the elderly may be associated with both quinine and quinidine usage.||Austin Authors:||Bird, M R;O'Neill, A I;Buchanan, Russell R C ;Ibrahim, K M;Des Parkin, J||Affiliation:||Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria||Issue Date:||Apr-1995||Publication information:||Pathology 1995; 27(2): 136-9||Abstract:||Thirty-one patients aged over 60 yrs and with lupus anticoagulant (LA) were reviewed for their drug intake. Twenty-three (73%) were taking cinchona alkaloids, 10 (32%) quinine for night cramps, 11 (35%) quinidine for cardiac arrhythmia and 2 (6%) were taking both. These frequencies of drugs usage differed significantly from age and sex matched controls (p < 0.001). Five patients had features suggestive of the antiphospholipid syndrome. Repeat testing showed persistent LA activity in all but 2 of 5 patients in whom the relevant drug had been ceased. This is the first description of a possible causal association between LA and quinine therapy.||URI:||https://ahro.austin.org.au/austinjspui/handle/1/27688||DOI:||10.1080/00313029500169742||Journal:||Pathology||PubMed URL:||7567140||ISSN:||0031-3025||Type:||Journal Article|
|Appears in Collections:||Journal articles|
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