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Title: Lupus anticoagulant in the elderly may be associated with both quinine and quinidine usage.
Austin Authors: Bird, M R;O'Neill, A I;Buchanan, Russell R C ;Ibrahim, K M;Des Parkin, J
Affiliation: Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria
Issue Date: Apr-1995
Publication information: Pathology 1995; 27(2): 136-9
Abstract: Thirty-one patients aged over 60 yrs and with lupus anticoagulant (LA) were reviewed for their drug intake. Twenty-three (73%) were taking cinchona alkaloids, 10 (32%) quinine for night cramps, 11 (35%) quinidine for cardiac arrhythmia and 2 (6%) were taking both. These frequencies of drugs usage differed significantly from age and sex matched controls (p < 0.001). Five patients had features suggestive of the antiphospholipid syndrome. Repeat testing showed persistent LA activity in all but 2 of 5 patients in whom the relevant drug had been ceased. This is the first description of a possible causal association between LA and quinine therapy.
DOI: 10.1080/00313029500169742
Journal: Pathology
PubMed URL: 7567140
ISSN: 0031-3025
Type: Journal Article
Appears in Collections:Journal articles

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