What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies.

Villemagne, Victor L; Lopresti, Brian J; Doré, Vincent; Tudorascu, Dana; Ikonomovic, Milos D; Burnham, Samantha; Minhas, Davneet; Pascoal, Tharick A; Mason, N Scott; Snitz, Beth; Aizenstein, Howard; Mathis, Chester A; Lopez, Oscar; Rowe, Christopher C; Klunk, William E; Cohen, Ann D

doi:10.2967/jnumed.120.245423

Title

What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies.

Publication Date

2021-05-10

Author(s)

Villemagne, Victor L

Lopresti, Brian J

Doré, Vincent

Tudorascu, Dana

Ikonomovic, Milos D

Burnham, Samantha

Minhas, Davneet

Pascoal, Tharick A

Mason, N Scott

Snitz, Beth

Aizenstein, Howard

Mathis, Chester A

Lopez, Oscar

Rowe, Christopher C

Klunk, William E

Cohen, Ann D

Subject

AT(N) framework

Alzheimer disease

biomarkers

brain imaging

tau imaging

Type of document

Journal Article

DOI

10.2967/jnumed.120.245423

Abstract

In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consensus on normal and abnormal tau imaging values that can be universally implemented in clinical research and therapeutic trials.

Link

link

Citation

Journal of Nuclear Medicine 2021; 62(5): 614-619

Jornal Title

Journal of Nuclear Medicine

Austin Health

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