Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26928
Title: Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.
Austin Authors: Zaborowski, Alexandra M;Abdile, Ahmed;Adamina, Michel;Aigner, Felix;d'Allens, Laura;Allmer, Caterina;Álvarez, Andrea;Anula, Rocio;Andric, Mihailo;Atallah, Sam;Bach, Simon;Bala, Miklosh;Barussaud, Marie;Bausys, Augustinas;Bebington, Brendan;Beggs, Andrew;Bellolio, Felipe;Bennett, Melissa-Rose;Berdinskikh, Anton;Bevan, Vicki;Biondo, Sebastiano;Bislenghi, Gabriele;Bludau, Marc;Boutall, Adam;Brouwer, Nelleke;Brown, Carl;Bruns, Christiane;Buchanan, Daniel D;Buchwald, Pamela;Burger, Jacobus W A;Burlov, Nikita;Campanelli, Michela;Capdepont, Maylis;Carvello, Michele;Chew, Hwee-Hoon;Christoforidis, Dimitri;Clark, David J ;Climent, Marta;Cologne, Kyle G;Contreras, Tomas;Croner, Roland;Daniels, Ian R;Dapri, Giovanni;Davies, Justin;Delrio, Paolo;Denost, Quentin;Deutsch, Michael;Dias, Andre;D'Hoore, André;Drozdov, Evgeniy;Duek, Daniel;Dunlop, Malcolm;Dziki, Adam;Edmundson, Aleksandra;Efetov, Sergey;El-Hussuna, Alaa;Elliot, Brodie;Emile, Sameh;Espin, Eloy;Evans, Martyn;Faes, Seraina;Faiz, Omar;Fleming, Fergal;Foppa, Caterina;Fowler, George;Frasson, Matteo;Figueiredo, Nuno;Forgan, Tim;Frizelle, Frank;Gadaev, Shamil;Gellona, Jose;Glyn, Tamara;Gong, Jianping;Goran, Barisic;Greenwood, Emma;Guren, Marianne G;Guillon, Stephanie;Gutlic, Ida;Hahnloser, Dieter;Hampel, Heather;Hanly, Ann;Hasegawa, Hirotoshi;Iversen, Lene Hjerrild;Hill, Andrew;Hill, James;Hoch, Jiri;Hoffmeister, Michael;Hompes, Roel;Hurtado, Luis;Iaquinandi, Fabiano;Imbrasaite, Ugne;Islam, Rumana;Jafari, Mehrenah Dorna;Kanemitsu, Yukihide;Karachun, Aleksei;Karimuddin, Ahmer A;Keller, Deborah S;Kelly, Justin;Kennelly, Rory;Khrykov, Gleb;Kocian, Peter;Koh, Cherry;Kok, Neils;Knight, Katrina A;Knol, Joep;Kontovounisios, Christos;Korner, Hartwig;Krivokapic, Zoran;Kronberger, Irmgard;Kroon, Hidde Maarten;Kryzauskas, Marius;Kural, Said;Kusters, Miranda;Lakkis, Zaher;Lankov, Timur;Larson, Dave;Lázár, György;Lee, Kai-Yin;Lee, Suk Hwan;Lefèvre, Jérémie H;Lepisto, Anna;Lieu, Christopher;Loi, Lynette;Lynch, Craig;Maillou-Martinaud, Helene;Maroli, Annalisa;Martin, Sean;Martling, Anna;Matzel, Klaus E;Mayol, Julio;McDermott, Frank;Meurette, Guillaume;Millan, Monica;Mitteregger, Martin;Moiseenko, Andrei;Monson, John R T;Morarasu, Stefan;Moritani, Konosuke;Möslein, Gabriela;Munini, Martino;Nahas, Caio;Nahas, Sergio;Negoi, Ionut;Novikova, Anastasia;Ocares, Misael;Okabayashi, Koji;Olkina, Alexandra;Oñate-Ocaña, Luis;Otero, Jaime;Ozen, Cihan;Pace, Ugo;São Julião, Guilherme Pagin;Panaiotti, Lidiia;Panis, Yves;Papamichael, Demetris;Park, Jason;Patel, Swati;Patrón Uriburu, Juan Carlos;Pera, Miguel;Perez, Rodrigo O;Petrov, Alexei;Pfeffer, Frank;Phang, P Terry;Poskus, Tomas;Pringle, Heather;Proud, David ;Raguz, Ivana;Rama, Nuno;Rasheed, Shahnawaz;Raval, Manoj J;Rega, Daniela;Reissfelder, Christoph;Reyes Meneses, Juan Carlos;Ris, Frederic;Riss, Stefan;Rodriguez-Zentner, Homero;Roxburgh, Campbell S;Saklani, Avanish;Salido, Andrea Jiménez;Sammour, Tarik;Saraste, Deborah;Schneider, Martin;Seishima, Ryo;Sekulic, Aleksandar;Seppala, Toni;Sheahan, Kieran;Shine, Rebecca;Shlomina, Alexandra;Sica, Guiseppe S;Singnomklao, Tongplaew;Siragusa, Leandro;Smart, Neil;Solis, Alejandro;Spinelli, Antonino;Staiger, Roxane D;Stamos, Michael J;Steele, Scott;Sunderland, Michael;Tan, Ker-Kan;Tanis, Pieter J;Tekkis, Paris;Teklay, Biniam;Tengku, Sabrina;Jiménez-Toscano, Marta;Tsarkov, Petr;Turina, Matthias;Ulrich, Alexis;Vailati, Bruna B;van Harten, Meike;Verhoef, Kees;Warrier, Satish;Wexner, Steve;de Wilt, Hans;Weinberg, Benjamin A;Wells, Cameron;Wolthuis, Albert;Xynos, Evangelos;You, Nancy;Zakharenko, Alexander;Zeballos, Justino;Winter, Des C
Affiliation: Department of Surgery, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland
Department of Surgery, Pontificia Universidad Catolica de Chile, Santiago, Chile
Department of Digestive Surgery, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
Department of Surgery, Bordeaux University Hospital, Bordeaux, France
Department of Surgery, University Hospital Poitiers, Poitiers, France
Department of Surgery, University Hospital La Fe, Valencia, Spain
Colorectal Surgery Unit, General Surgery Service, Hospital Vall de Hebron, Barcelona, Spain
Department of Surgery, Bellvitge University Hospital, Barcelona, Spain
Department of Surgery, Champalimaud Clinical Centre, Lisbon, Portugal
Department of Surgery, St Vincent's Hospital, University of Melbourne, Melbourne, Australia
Department of Clinical Pathology, the University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, Australia
Department of Colorectal Surgery, Clínica Santa María, Santiago, Chile
Department of Surgery, Royal Prince Alfred Hospital, Sydney, Australia
Department of Surgery, Peter MacCallum Cancer Centre, Melbourne, Australia
Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Surgery
Department of Surgery, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia
Department of Surgery, University Hospital Geneva, Geneva, Switzerland
Department of Surgery, University Hospital Zurich, Zurich, Switzerland
Department of Surgery, Lugano Regional Hospital, Lugano, Switzerland
Department of Surgery, Cantonal Hospital, Winterthur, Switzerland
Department of Visceral Surgery, University Hospital Lausanne, Lausanne, Switzerland
Department of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan
Department of Surgery, Keio University, Tokyo, Japan
Department of Surgery, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan
Department of Colorectal Surgery, Hospital Militar de Santiago, Le Reina, Chile
Department of Surgery, Tongji Hospital, Wuhan, China
School of Medicine, Uludag University, Bursa, Turkey
Sorbonne Université, Department of Digestive Surgery, Assistance Publique-Hôpitaux de Paris, Hôpital St Antoine, Paris, France
Department of Surgery, University Hospital Besançon, Besançon, France
Kyung Here University Hospital at Gangdong, Seoul, South Korea
Department of Surgery, St Paul's Hospital, Vancouver, British Columbia, Canada
Department of Surgery, St Boniface General Hospital, Winnipeg, Manitoba, Canada
Department of Surgery, University Hospital Concepción, Concepción, Chile
Department of Surgery, Beaujon Hospital, Paris, France
Department of Surgery, University Hospital Nantes, Nantes, France
Department of Surgery, La Fe University Hospital, Valencia, Spain
Department of Surgery, Centro Hospitalar de Leiria, Leiria, Portugal
Department of Surgery, Instituto de Investigación Sanitaria San Carlos, Universidad Complutense de Madrid, Hospital Clínico San Carlos, Madrid, Spain
Department of Surgery, Tata Memorial Centre, Mumbai, India
Department of Surgery, Hospital del Mar, Barcelona, Spain
Department of Surgery, Creta Inter-Clinic Hospital, Heraklion, Crete, Greece
Department of Surgery, St Paul's Hospital, the University of British Columbia, Vancouver, British Columbia, Canada
Department of Surgery, Middlemore Hospital, Auckland, New Zealand
Department of Surgery, Barmherzige Brüder Krankenhaus Graz, Graz, Austria
Department of Surgery, University Hospital Magdeburg, Magdeburg, Germany
Department of Colorectal Surgery, AdventHealth, Orlando, Florida
Department of Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom
Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Department of Surgery, National Cancer Institute, Vilnius, Lithuania
Department of Surgery, Wits Donald Gordon Medical Centre, Johannesburg, South Africa
Department of Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom
Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom
Department of Surgery, St-Petersburg Clinical Scientific and Practical Centre, St Petersburg, Russia
Department of Surgery, Morriston Hospital, Swansea, Wales, United Kingdom
Department of Surgery, UZ Leuven, Leuven, Belgium
Department of Surgery, University Hospital Cologne, Cologne, Germany
Department of Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands
Department of Surgery, University Hospital Cologne, Cologne, Germany
Department of Surgery, Skåne University Hospital, Malmö, Sweden
Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands
Department of Surgery, Leningrad Regional Clinical Oncology Dispensary, Leningrad, Russia
Department of Surgery, Policlinico Tor Vergata, Rome, Italy
Division of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore
Department of Surgery, Keck Hospital, University of Southern California, Los Angeles
Department of Surgery, University Hospital Magdeburg, Magdeburg, Germany
Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom
Department of Surgery, St-Pierre University Hospital, Brussels, Belgium
Cambridge Colorectal Unit, Addenbrooke's Hospital, Cambridge, United Kingdom
Colorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G. Pascale" IRCSS, Naples, Italy
Department of Surgery, Milton S. Hershey Medical Center, Hershey, Pennsylvania
Department of Surgery, Institute of Cancer of São Paulo, São Paulo, Brazil
Department of Surgery, UZ Leuven, Leuven, Belgium
Department of Surgery, Siberian State Medical University, Tomsk, Russia
Department of Surgery, Rambam Health Care Campus, Haifa, Israel
Department of Surgery, Western General Hospital, Edinburgh, United Kingdom
Department of Surgery, Military Medical Academy University Teaching Hospital, Łódź, Poland
Department of Surgery, Sechenov First Moscow State Medical University, Moscow, Russia
Department of Surgery, Aalborg University Hospital, Aalborg, Denmark
Department of Surgery, Whangarei Hospital, Whangarei, New Zealand
Department of Surgery, Mansoura University Hospital, Mansoura, Egypt
Department of Surgery, Morriston Hospital, Swansea, Wales, United Kingdom
Department of Surgery, St Mark's Hospital, London, United Kingdom
Department of Surgery, University of Rochester, New York
Division of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom
Department of Surgery, Tygerberg Academic Hospital, Cape Town, South Africa
Department of Surgery, Christchurch Hospital, Christchurch, New Zealand
Fourth Coloproctology Department, St Petersburg Oncology Center, St Petersburg, Russia
Department of Surgery, Christchurch Hospital, Christchurch, New Zealand
Department of Surgery, Clinical Center of Serbia, Belgrade, Serbia
Department of Oncology, Oslo University Hospital, Oslo, Norway
Department of Surgery, Skåne University Hospital, Malmö, Sweden
Division of Human Genetics, The Ohio State University Comprehensive Cancer Center, Columbus
Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland
Department of Surgery, Aarhus University Hospital, Aarhus, Denmark
Department of Surgery, Middlemore Hospital, Auckland, New Zealand
Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom
Department of Surgery, Motol University Hospital, Prague, Czech Republic
Department of Surgery, German Cancer Research Center, Heidelberg, Germany
Department of Surgery, Amsterdam University Medical Center, Amsterdam, The Netherlands
Vilnius University, Faculty of Medicine, Vilnius, Lithuania
School of Medicine, University of California Irvine, Irvine
Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia
Division of Colorectal Surgery, Department of Surgery, University of California at Davis Medical Center, Sacramento
Advent Health Colorectal Surgery, Orlando, Florida
Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland
Department of Surgery, Leningrad Regional Clinical Oncology Dispensary, Leningrad, Russia
Department of Surgery, Motol University Hospital, Prague, Czech Republic
Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands
University of Glasgow, Glasgow, United Kingdom
Department of Surgery, Ziekenhuis Oost-Limburg, Belgium
Department of Surgery, Royal Marsden Hospital, London, United Kingdom
Department of Surgery, Stavanger University Hospital, Stavanger, Norway
Department of Surgery, Clinical Center of Serbia, Belgrade, Serbia
Medical University Innsbruck, Innsbruck, Austria
Vilnius University, Faculty of Medicine, Vilnius, Lithuania
Department of Surgery, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia
Department of Surgery, Mayo Clinic, Rochester, Minnesota
Department of Surgery, University of Szeged, Szeged, Hungary
Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore
Department of Surgery, Helsinki University Hospital, Helsinki, Finland
Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora
University of Glasgow, Glasgow, United Kingdom
Division of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland
Department of Surgery, Karolinska University Hospital, Stockholm, Sweden
Department of Surgery, University Hospital Erlangen, Erlangen, Germany
Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom
Department of Surgery, Barmherzige Brüder Krankenhaus Graz, Graz, Austria
Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia
AdventHealth Medical Group Colorectal Surgery, AdventHealth, Orlando, Florida
Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland
Department for Hereditary Tumors, Evangelisches Krankenhaus Bethesda, Duisburg, Germany
Department of Surgery, Institute of Cancer of São Paulo, São Paulo, Brazil
Department of Surgery, Emergency Hospital of Bucharest, Bucharest, Romania
Department of Surgery, Pavlov First St Petersburg State Medical University's Clinic, St Petersburg, Russia
Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia
Department of Surgery, National Cancer Institute, Mexico City, Mexico
Department of Surgery, Aalborg University Hospital, Aalborg, Denmark
Colorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G. Pascale" IRCSS, Naples, Italy
Department of Surgery, Angelita and Joaquim Gama Institute, São Paulo, Brazil
Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia
Department of Medical Oncology, Bank of Cyprus Oncology Centre, Nicosia, Cyprus
Department of Gastroenterology, University of Colorado Anschutz Medical Campus, Aurora
Colorectal Surgery Department, British Hospital of Buenos Aires, Buenos Aires, Argentina
Colorectal Surgery Division, Angelita and Joaquim Gama Institute, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil
Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia
Department of Surgery, Haukeland University Hospital, Bergen, Norway
Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom
Department of Surgery, Royal Marsden Hospital, London, United Kingdom
Colorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G. Pascale" IRCSS, Naples, Italy
Department of Surgery, Mannheim University Hospital, Mannheim, Germany
Department of Surgery, Colombia National University Hospital, Bogota, Columbia
Department of Surgery, Medical University Vienna, Vienna, Austria
Department of Surgery, Hospital Punta Pacífica, Panama City, Panama
Glasgow Royal Infirmary, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
Department of Surgery, Stockholm South General Hospital, Stockholm, Sweden
Department of Surgery, Heidelberg University Hospital, Heidelberg, Germany
Department of Surgery, Clinical Center of Serbia, Belgrade, Serbia
Department of Surgery, Helsinki University Hospital, Helsinki, Finland
Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland
Department of Surgery, Sechenov First Moscow State Medical University, Moscow, Russia
Department of Surgery, Policlinico Tor Vergata, Rome, Italy
Department of Surgery, Karolinska University Hospital, Stockholm, Sweden
Department of Surgery, Policlinico Tor Vergata, Rome, Italy
Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom
Department of Biomedical Sciences, Humanitas University, Division of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
School of Medicine, University of California Irvine, Irvine
Department of Surgery, Cleveland Clinic, Cleveland, Ohio
Department of Surgery, Whangarei Hospital, Whangarei, New Zealand
Department of Surgery, School of Medicine, National University of Singapore, Singapore, Singapore
Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Cancer Centre Amsterdam, Amsterdam, The Netherlands
Department of Surgery, Royal Marsden Hospital, London, United Kingdom
Department of Surgery, Åbenrå Hospital, Åbenrå, Denmark
University of Glasgow, Glasgow, United Kingdom
Department of Surgery, Sechenov First Moscow State Medical University, Moscow, Russia
Department of Surgery, Lukas Hospital, Neuss, Germany
Department of Surgery, Angelita and Joaquim Gama Institute, São Paulo, Brazil
Department of Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands
Department of Surgery, Cleveland Clinic Florida, Weston
Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC
Department of Surgery, Auckland City Hospital, Auckland, New Zealand
Department of Surgery, UZ Leuven, Leuven, Belgium
Department of Surgery, MD Anderson Cancer Center, Houston, Texas
Department of Surgery, Pavlov First St Petersburg State Medical University's Clinic, St Petersburg, Russia
Department of Surgery, Maciel Hospital, Montevideo, Uruguay
Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland
Issue Date: 30-Jun-2021
Date: 2021-06-30
Publication information: JAMA Surgery 2021; online first: 30 June
Abstract: The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer. Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts. The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.
URI: https://ahro.austin.org.au/austinjspui/handle/1/26928
DOI: 10.1001/jamasurg.2021.2380
Journal: JAMA Surgery
PubMed URL: 34190968
Type: Journal Article
Appears in Collections:Journal articles

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