Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/26928
Title: | Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review. | Austin Authors: | Zaborowski, Alexandra M;Abdile, Ahmed;Adamina, Michel;Aigner, Felix;d'Allens, Laura;Allmer, Caterina;Álvarez, Andrea;Anula, Rocio;Andric, Mihailo;Atallah, Sam;Bach, Simon;Bala, Miklosh;Barussaud, Marie;Bausys, Augustinas;Bebington, Brendan;Beggs, Andrew;Bellolio, Felipe;Bennett, Melissa-Rose;Berdinskikh, Anton;Bevan, Vicki;Biondo, Sebastiano;Bislenghi, Gabriele;Bludau, Marc;Boutall, Adam;Brouwer, Nelleke;Brown, Carl;Bruns, Christiane;Buchanan, Daniel D;Buchwald, Pamela;Burger, Jacobus W A;Burlov, Nikita;Campanelli, Michela;Capdepont, Maylis;Carvello, Michele;Chew, Hwee-Hoon;Christoforidis, Dimitri;Clark, David J ;Climent, Marta;Cologne, Kyle G;Contreras, Tomas;Croner, Roland;Daniels, Ian R;Dapri, Giovanni;Davies, Justin;Delrio, Paolo;Denost, Quentin;Deutsch, Michael;Dias, Andre;D'Hoore, André;Drozdov, Evgeniy;Duek, Daniel;Dunlop, Malcolm;Dziki, Adam;Edmundson, Aleksandra;Efetov, Sergey;El-Hussuna, Alaa;Elliot, Brodie;Emile, Sameh;Espin, Eloy;Evans, Martyn;Faes, Seraina;Faiz, Omar;Fleming, Fergal;Foppa, Caterina;Fowler, George;Frasson, Matteo;Figueiredo, Nuno;Forgan, Tim;Frizelle, Frank;Gadaev, Shamil;Gellona, Jose;Glyn, Tamara;Gong, Jianping;Goran, Barisic;Greenwood, Emma;Guren, Marianne G;Guillon, Stephanie;Gutlic, Ida;Hahnloser, Dieter;Hampel, Heather;Hanly, Ann;Hasegawa, Hirotoshi;Iversen, Lene Hjerrild;Hill, Andrew;Hill, James;Hoch, Jiri;Hoffmeister, Michael;Hompes, Roel;Hurtado, Luis;Iaquinandi, Fabiano;Imbrasaite, Ugne;Islam, Rumana;Jafari, Mehrenah Dorna;Kanemitsu, Yukihide;Karachun, Aleksei;Karimuddin, Ahmer A;Keller, Deborah S;Kelly, Justin;Kennelly, Rory;Khrykov, Gleb;Kocian, Peter;Koh, Cherry;Kok, Neils;Knight, Katrina A;Knol, Joep;Kontovounisios, Christos;Korner, Hartwig;Krivokapic, Zoran;Kronberger, Irmgard;Kroon, Hidde Maarten;Kryzauskas, Marius;Kural, Said;Kusters, Miranda;Lakkis, Zaher;Lankov, Timur;Larson, Dave;Lázár, György;Lee, Kai-Yin;Lee, Suk Hwan;Lefèvre, Jérémie H;Lepisto, Anna;Lieu, Christopher;Loi, Lynette;Lynch, Craig;Maillou-Martinaud, Helene;Maroli, Annalisa;Martin, Sean;Martling, Anna;Matzel, Klaus E;Mayol, Julio;McDermott, Frank;Meurette, Guillaume;Millan, Monica;Mitteregger, Martin;Moiseenko, Andrei;Monson, John R T;Morarasu, Stefan;Moritani, Konosuke;Möslein, Gabriela;Munini, Martino;Nahas, Caio;Nahas, Sergio;Negoi, Ionut;Novikova, Anastasia;Ocares, Misael;Okabayashi, Koji;Olkina, Alexandra;Oñate-Ocaña, Luis;Otero, Jaime;Ozen, Cihan;Pace, Ugo;São Julião, Guilherme Pagin;Panaiotti, Lidiia;Panis, Yves;Papamichael, Demetris;Park, Jason;Patel, Swati;Patrón Uriburu, Juan Carlos;Pera, Miguel;Perez, Rodrigo O;Petrov, Alexei;Pfeffer, Frank;Phang, P Terry;Poskus, Tomas;Pringle, Heather;Proud, David ;Raguz, Ivana;Rama, Nuno;Rasheed, Shahnawaz;Raval, Manoj J;Rega, Daniela;Reissfelder, Christoph;Reyes Meneses, Juan Carlos;Ris, Frederic;Riss, Stefan;Rodriguez-Zentner, Homero;Roxburgh, Campbell S;Saklani, Avanish;Salido, Andrea Jiménez;Sammour, Tarik;Saraste, Deborah;Schneider, Martin;Seishima, Ryo;Sekulic, Aleksandar;Seppala, Toni;Sheahan, Kieran;Shine, Rebecca;Shlomina, Alexandra;Sica, Guiseppe S;Singnomklao, Tongplaew;Siragusa, Leandro;Smart, Neil;Solis, Alejandro;Spinelli, Antonino;Staiger, Roxane D;Stamos, Michael J;Steele, Scott;Sunderland, Michael;Tan, Ker-Kan;Tanis, Pieter J;Tekkis, Paris;Teklay, Biniam;Tengku, Sabrina;Jiménez-Toscano, Marta;Tsarkov, Petr;Turina, Matthias;Ulrich, Alexis;Vailati, Bruna B;van Harten, Meike;Verhoef, Kees;Warrier, Satish;Wexner, Steve;de Wilt, Hans;Weinberg, Benjamin A;Wells, Cameron;Wolthuis, Albert;Xynos, Evangelos;You, Nancy;Zakharenko, Alexander;Zeballos, Justino;Winter, Des C | Affiliation: | Department of Surgery, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland Department of Surgery, Pontificia Universidad Catolica de Chile, Santiago, Chile Department of Digestive Surgery, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile Department of Surgery, Bordeaux University Hospital, Bordeaux, France Department of Surgery, University Hospital Poitiers, Poitiers, France Department of Surgery, University Hospital La Fe, Valencia, Spain Colorectal Surgery Unit, General Surgery Service, Hospital Vall de Hebron, Barcelona, Spain Department of Surgery, Bellvitge University Hospital, Barcelona, Spain Department of Surgery, Champalimaud Clinical Centre, Lisbon, Portugal Department of Surgery, St Vincent's Hospital, University of Melbourne, Melbourne, Australia Department of Clinical Pathology, the University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, Australia Department of Colorectal Surgery, Clínica Santa María, Santiago, Chile Department of Surgery, Royal Prince Alfred Hospital, Sydney, Australia Department of Surgery, Peter MacCallum Cancer Centre, Melbourne, Australia Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia Surgery Department of Surgery, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia Department of Surgery, University Hospital Geneva, Geneva, Switzerland Department of Surgery, University Hospital Zurich, Zurich, Switzerland Department of Surgery, Lugano Regional Hospital, Lugano, Switzerland Department of Surgery, Cantonal Hospital, Winterthur, Switzerland Department of Visceral Surgery, University Hospital Lausanne, Lausanne, Switzerland Department of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan Department of Surgery, Keio University, Tokyo, Japan Department of Surgery, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan Department of Colorectal Surgery, Hospital Militar de Santiago, Le Reina, Chile Department of Surgery, Tongji Hospital, Wuhan, China School of Medicine, Uludag University, Bursa, Turkey Sorbonne Université, Department of Digestive Surgery, Assistance Publique-Hôpitaux de Paris, Hôpital St Antoine, Paris, France Department of Surgery, University Hospital Besançon, Besançon, France Kyung Here University Hospital at Gangdong, Seoul, South Korea Department of Surgery, St Paul's Hospital, Vancouver, British Columbia, Canada Department of Surgery, St Boniface General Hospital, Winnipeg, Manitoba, Canada Department of Surgery, University Hospital Concepción, Concepción, Chile Department of Surgery, Beaujon Hospital, Paris, France Department of Surgery, University Hospital Nantes, Nantes, France Department of Surgery, La Fe University Hospital, Valencia, Spain Department of Surgery, Centro Hospitalar de Leiria, Leiria, Portugal Department of Surgery, Instituto de Investigación Sanitaria San Carlos, Universidad Complutense de Madrid, Hospital Clínico San Carlos, Madrid, Spain Department of Surgery, Tata Memorial Centre, Mumbai, India Department of Surgery, Hospital del Mar, Barcelona, Spain Department of Surgery, Creta Inter-Clinic Hospital, Heraklion, Crete, Greece Department of Surgery, St Paul's Hospital, the University of British Columbia, Vancouver, British Columbia, Canada Department of Surgery, Middlemore Hospital, Auckland, New Zealand Department of Surgery, Barmherzige Brüder Krankenhaus Graz, Graz, Austria Department of Surgery, University Hospital Magdeburg, Magdeburg, Germany Department of Colorectal Surgery, AdventHealth, Orlando, Florida Department of Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel Department of Surgery, National Cancer Institute, Vilnius, Lithuania Department of Surgery, Wits Donald Gordon Medical Centre, Johannesburg, South Africa Department of Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom Department of Surgery, St-Petersburg Clinical Scientific and Practical Centre, St Petersburg, Russia Department of Surgery, Morriston Hospital, Swansea, Wales, United Kingdom Department of Surgery, UZ Leuven, Leuven, Belgium Department of Surgery, University Hospital Cologne, Cologne, Germany Department of Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands Department of Surgery, University Hospital Cologne, Cologne, Germany Department of Surgery, Skåne University Hospital, Malmö, Sweden Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands Department of Surgery, Leningrad Regional Clinical Oncology Dispensary, Leningrad, Russia Department of Surgery, Policlinico Tor Vergata, Rome, Italy Division of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore Department of Surgery, Keck Hospital, University of Southern California, Los Angeles Department of Surgery, University Hospital Magdeburg, Magdeburg, Germany Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom Department of Surgery, St-Pierre University Hospital, Brussels, Belgium Cambridge Colorectal Unit, Addenbrooke's Hospital, Cambridge, United Kingdom Colorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G. Pascale" IRCSS, Naples, Italy Department of Surgery, Milton S. Hershey Medical Center, Hershey, Pennsylvania Department of Surgery, Institute of Cancer of São Paulo, São Paulo, Brazil Department of Surgery, UZ Leuven, Leuven, Belgium Department of Surgery, Siberian State Medical University, Tomsk, Russia Department of Surgery, Rambam Health Care Campus, Haifa, Israel Department of Surgery, Western General Hospital, Edinburgh, United Kingdom Department of Surgery, Military Medical Academy University Teaching Hospital, Łódź, Poland Department of Surgery, Sechenov First Moscow State Medical University, Moscow, Russia Department of Surgery, Aalborg University Hospital, Aalborg, Denmark Department of Surgery, Whangarei Hospital, Whangarei, New Zealand Department of Surgery, Mansoura University Hospital, Mansoura, Egypt Department of Surgery, Morriston Hospital, Swansea, Wales, United Kingdom Department of Surgery, St Mark's Hospital, London, United Kingdom Department of Surgery, University of Rochester, New York Division of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom Department of Surgery, Tygerberg Academic Hospital, Cape Town, South Africa Department of Surgery, Christchurch Hospital, Christchurch, New Zealand Fourth Coloproctology Department, St Petersburg Oncology Center, St Petersburg, Russia Department of Surgery, Christchurch Hospital, Christchurch, New Zealand Department of Surgery, Clinical Center of Serbia, Belgrade, Serbia Department of Oncology, Oslo University Hospital, Oslo, Norway Department of Surgery, Skåne University Hospital, Malmö, Sweden Division of Human Genetics, The Ohio State University Comprehensive Cancer Center, Columbus Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland Department of Surgery, Aarhus University Hospital, Aarhus, Denmark Department of Surgery, Middlemore Hospital, Auckland, New Zealand Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom Department of Surgery, Motol University Hospital, Prague, Czech Republic Department of Surgery, German Cancer Research Center, Heidelberg, Germany Department of Surgery, Amsterdam University Medical Center, Amsterdam, The Netherlands Vilnius University, Faculty of Medicine, Vilnius, Lithuania School of Medicine, University of California Irvine, Irvine Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia Division of Colorectal Surgery, Department of Surgery, University of California at Davis Medical Center, Sacramento Advent Health Colorectal Surgery, Orlando, Florida Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland Department of Surgery, Leningrad Regional Clinical Oncology Dispensary, Leningrad, Russia Department of Surgery, Motol University Hospital, Prague, Czech Republic Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands University of Glasgow, Glasgow, United Kingdom Department of Surgery, Ziekenhuis Oost-Limburg, Belgium Department of Surgery, Royal Marsden Hospital, London, United Kingdom Department of Surgery, Stavanger University Hospital, Stavanger, Norway Department of Surgery, Clinical Center of Serbia, Belgrade, Serbia Medical University Innsbruck, Innsbruck, Austria Vilnius University, Faculty of Medicine, Vilnius, Lithuania Department of Surgery, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia Department of Surgery, Mayo Clinic, Rochester, Minnesota Department of Surgery, University of Szeged, Szeged, Hungary Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore Department of Surgery, Helsinki University Hospital, Helsinki, Finland Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora University of Glasgow, Glasgow, United Kingdom Division of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland Department of Surgery, Karolinska University Hospital, Stockholm, Sweden Department of Surgery, University Hospital Erlangen, Erlangen, Germany Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom Department of Surgery, Barmherzige Brüder Krankenhaus Graz, Graz, Austria Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia AdventHealth Medical Group Colorectal Surgery, AdventHealth, Orlando, Florida Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland Department for Hereditary Tumors, Evangelisches Krankenhaus Bethesda, Duisburg, Germany Department of Surgery, Institute of Cancer of São Paulo, São Paulo, Brazil Department of Surgery, Emergency Hospital of Bucharest, Bucharest, Romania Department of Surgery, Pavlov First St Petersburg State Medical University's Clinic, St Petersburg, Russia Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia Department of Surgery, National Cancer Institute, Mexico City, Mexico Department of Surgery, Aalborg University Hospital, Aalborg, Denmark Colorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G. Pascale" IRCSS, Naples, Italy Department of Surgery, Angelita and Joaquim Gama Institute, São Paulo, Brazil Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia Department of Medical Oncology, Bank of Cyprus Oncology Centre, Nicosia, Cyprus Department of Gastroenterology, University of Colorado Anschutz Medical Campus, Aurora Colorectal Surgery Department, British Hospital of Buenos Aires, Buenos Aires, Argentina Colorectal Surgery Division, Angelita and Joaquim Gama Institute, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil Surgical Department of Abdominal Oncology, N. N. Petrov National Medical Research Centre of Oncology, St Petersburg, Russia Department of Surgery, Haukeland University Hospital, Bergen, Norway Faculty of Medicine, Vilnius University, Vilnius, Lithuania Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom Department of Surgery, Royal Marsden Hospital, London, United Kingdom Colorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G. Pascale" IRCSS, Naples, Italy Department of Surgery, Mannheim University Hospital, Mannheim, Germany Department of Surgery, Colombia National University Hospital, Bogota, Columbia Department of Surgery, Medical University Vienna, Vienna, Austria Department of Surgery, Hospital Punta Pacífica, Panama City, Panama Glasgow Royal Infirmary, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom Department of Surgery, Stockholm South General Hospital, Stockholm, Sweden Department of Surgery, Heidelberg University Hospital, Heidelberg, Germany Department of Surgery, Clinical Center of Serbia, Belgrade, Serbia Department of Surgery, Helsinki University Hospital, Helsinki, Finland Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland Department of Surgery, Sechenov First Moscow State Medical University, Moscow, Russia Department of Surgery, Policlinico Tor Vergata, Rome, Italy Department of Surgery, Karolinska University Hospital, Stockholm, Sweden Department of Surgery, Policlinico Tor Vergata, Rome, Italy Department of Surgery, Royal Devon and Exeter Hospital, Exeter, United Kingdom Department of Biomedical Sciences, Humanitas University, Division of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy School of Medicine, University of California Irvine, Irvine Department of Surgery, Cleveland Clinic, Cleveland, Ohio Department of Surgery, Whangarei Hospital, Whangarei, New Zealand Department of Surgery, School of Medicine, National University of Singapore, Singapore, Singapore Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Cancer Centre Amsterdam, Amsterdam, The Netherlands Department of Surgery, Royal Marsden Hospital, London, United Kingdom Department of Surgery, Åbenrå Hospital, Åbenrå, Denmark University of Glasgow, Glasgow, United Kingdom Department of Surgery, Sechenov First Moscow State Medical University, Moscow, Russia Department of Surgery, Lukas Hospital, Neuss, Germany Department of Surgery, Angelita and Joaquim Gama Institute, São Paulo, Brazil Department of Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands Department of Surgery, Cleveland Clinic Florida, Weston Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC Department of Surgery, Auckland City Hospital, Auckland, New Zealand Department of Surgery, UZ Leuven, Leuven, Belgium Department of Surgery, MD Anderson Cancer Center, Houston, Texas Department of Surgery, Pavlov First St Petersburg State Medical University's Clinic, St Petersburg, Russia Department of Surgery, Maciel Hospital, Montevideo, Uruguay Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland |
Issue Date: | 30-Jun-2021 | Date: | 2021-06-30 | Publication information: | JAMA Surgery 2021; online first: 30 June | Abstract: | The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer. Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts. The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/26928 | DOI: | 10.1001/jamasurg.2021.2380 | Journal: | JAMA Surgery | PubMed URL: | 34190968 | Type: | Journal Article |
Appears in Collections: | Journal articles |
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.