Matched Case-Control Study of the Long-Term Impact of Beta-Lactam Antibiotic Allergy Testing.

2020-11-17

Trubiano, Jason

Marhoon, Nada

Vogrin, Sara

Chua, Kyra Y L

Holmes, Natasha E

adverse drug effects

allergy

allergy testing

antibiotic allergy

antimicrobial allergy

antimicrobial resistance

antimicrobial stewardship

beta-lactam allergy

beta-lactams

penicillin allergy

Journal Article

0000-0002-5111-6367

10.1128/AAC.01823-20

Whereas the short-term impacts of antibiotic allergy testing on delabeling and antibiotic usage have been demonstrated, the long-term impacts have been less well defined. In a single-center matched case-control study from Melbourne, Australia, we demonstrate that a beta-lactam antibiotic allergy testing program has a significant impact on antibiotic usage and infection-related outcomes. This study supports implementation of an antibiotic allergy testing program as a standard of care of antimicrobial stewardship programs.

link

Antimicrobial Agents and Chemotherapy 2020; 64(12): e01823-20

Antimicrobial Agents and Chemotherapy