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Title: N-Acetylcysteine reduces addiction-like behaviour towards high-fat high-sugar food in diet-induced obese rats.
Austin Authors: Sketriene, Diana;Battista, Damien;Perry, Christina J;Sumithran, Priya ;Lawrence, Andrew J;Brow, Robyn M
Affiliation: Endocrinology
The Florey Institute of Neuroscience and Mental Health, Mental Health Research Theme, Parkville, Melbourne, Australia
The Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Melbourne, Australia
Medicine (University of Melbourne)
Issue Date: Aug-2021
Date: 2021-05-24
Publication information: The European Journal of Neuroscience 2021; 54(3): 4877-4887
Abstract: Compulsive forms of eating displayed by some obese individuals share similarities with compulsive drug taking behaviour, a hallmark feature of substance use disorder. This raises the possibility that drug addiction treatments may show utility in the treatment of compulsive overeating. N-Acetylcysteine (NAC) is a cysteine pro-drug which has experienced some success in clinical trials, reducing cocaine, marijuana and cigarette use, as well as compulsive behaviours such as gambling and trichotillomania. We assessed the impact of NAC on addiction-like behaviour towards highly palatable food in a rat model of diet-induced obesity. Adult male Sprague-Dawley rats were placed on a high-fat high-sugar diet for eight weeks and then assigned to diet-induced obesity-prone (DIO) or diet-induced obesity-resistant (DR) groups based on weight gain. DIO and DR rats were subjected to an operant conditioning paradigm whereby rats could lever press for high-fat high-sugar food pellets. This alternated with periods of signalled reward unavailability. Before treatment DIO rats ate more in their home cage, earned more food pellets in operant sessions, and responded more during periods that signalled reward unavailability (suggestive of compulsive-like food seeking) compared to DR rats. This persistent responding in the absence of reward displayed by DIO rats was ameliorated by daily injections of NAC (100 mg/kg, i.p.) for 14 days. By the end of the treatment period, lever-pressing by NAC-treated DIO rats resembled that of DR rats. These findings suggest that NAC reduces addiction-like behaviour towards food in rats and supports the potential use of this compound in compulsive overeating.
DOI: 10.1111/ejn.15321
ORCID: 0000-0001-6836-727X
Journal: The European Journal of Neuroscience
PubMed URL: 34028895
Type: Journal Article
Subjects: N-acetylcysteine
compulsive eating
diet-induced obesity
high-fat high-sugar diet
Appears in Collections:Journal articles

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