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Title: Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.
Austin Authors: Lim, Wei Ling Florence;Huynh, Kevin;Chatterjee, Pratishtha;Martins, Ian;Jayawardana, Kaushala S;Giles, Corey;Mellett, Natalie A;Laws, Simon M;Bush, Ashley I;Rowe, Christopher C ;Villemagne, Victor L ;Ames, David;Drew, Brian G;Masters, Colin L ;Meikle, Peter J;Martins, Ralph N
Affiliation: National Ageing Research Institute, Parkville, Victoria, VIC, Australia
School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Perth, WA, Australia
Australian Alzheimer's Research Foundation, Nedlands, Western Australia, WA, Australia
Baker Heart and Diabetes Institute, Melbourne, Victoria, VIC, Australia
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, WA, Australia
Cooperative Research Centre (CRC) for Mental Health, Australia
Monash University, Melbourne, Victoria, VIC, Australia
Department of Biomedical Sciences, Macquarie University, North Ryde, New South Wales, NSW, Australia
KaRa Institute of Neurological Disease, Sydney, Macquarie Park, New South Wales, NSW, Australia
Collaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, WA, Australia
School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Western Australia, WA, Australia
The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Victoria, VIC, Australia
Molecular Imaging and Therapy
Medicine (University of Melbourne)
Issue Date: 2020
Publication information: Journal of Alzheimer's Disease : JAD 2020; 76(1): 303-315
Abstract: Lipid metabolism is altered in Alzheimer's disease (AD); however, the relationship between AD risk factors (age, APOEɛ4, and gender) and lipid metabolism is not well defined. We investigated whether altered lipid metabolism associated with increased age, gender, and APOE status may contribute to the development of AD by examining these risk factors in healthy controls and also clinically diagnosed AD individuals. We performed plasma lipidomic profiling (582 lipid species) of the Australian Imaging, Biomarkers and Lifestyle flagship study of aging cohort (AIBL) using liquid chromatography-mass spectrometry. Linear regression and interaction analysis were used to explore the relationship between risk factors and plasma lipid species. We observed strong associations between plasma lipid species with gender and increasing age in cognitively normal individuals. However, APOEɛ4 was relatively weakly associated with plasma lipid species. Interaction analysis identified differential associations of sphingolipids and polyunsaturated fatty acid esterified lipid species with AD based on age and gender, respectively. These data indicate that the risk associated with age, gender, and APOEɛ4 may, in part, be mediated by changes in lipid metabolism. This study extends our existing knowledge of the relationship between the lipidome and AD and highlights the complexity of the relationships between lipid metabolism and AD at different ages and between men and women. This has important implications for how we assess AD risk and also for potential therapeutic strategies involving modulation of lipid metabolic pathways.
DOI: 10.3233/JAD-191304
Journal: Journal of Alzheimer's Disease : JAD
PubMed URL: 32474467
Type: Journal Article
Subjects: APOEɛ4
Alzheimer’s disease
lipid species
Appears in Collections:Journal articles

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