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Title: Advanced glycation end products as predictors of renal function in youth with type 1 diabetes.
Austin Authors: Forbes, Josephine M;Le Bagge, Selena;Righi, Samuel;Fotheringham, Amelia K;Gallo, Linda A;McCarthy, Domenica A;Leung, Sherman;Baskerville, Tracey;Nisbett, Janelle;Morton, Adam;Teasdale, Stephanie;D'Silva, Neisha;Barrett, Helen;Jones, Timothy;Couper, Jennifer;Donaghue, Kim;Isbel, Nicole;Johnson, David W;Donnellan, Leigh;Deo, Permal;Akison, Lisa K;Moritz, Karen M;O'Moore-Sullivan, Trisha
Affiliation: Telethon Kid's Institute, Perth, WA, Australia
Children's Hospital at Westmead, Sydney, NSW, Australia
Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia
Mater Research Institute, The University of Queensland, TRI, 37 Kent Street, Brisbane, QLD, 4102, Australia
School of Biomedical Science and Faculty of Medicine, The University of Queensland, St Lucia, QLD, Australia
Medicine (University of Melbourne)
Mater Young Adults Health Centre, Mater Health Service, Brisbane, QLD, Australia
The Metro South and Ipswich Nephrology and Transplant Service (MINTS), Brisbane, QLD, Australia
Child Health Research Centre, The University of Queensland, South Brisbane, QLD, Australia
Health and Biomedical Innovation, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia
Issue Date: 3-May-2021
Date: 2021-05-03
Publication information: Scientific Reports 2021; 11(1): 9422
Abstract: To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/mol; diabetes duration 10.7 ± 5.2 years; BMI 24.5(5.3) kg/m2) and healthy controls (N = 299; 20.3 ± 1.8 years; M:F-83:116; FBG 5.2 ± 0.8 mmol/L; BMI 22.5(3.3) kg/m2) were recruited. Skin autofluorescence (sAF) and circulating AGEs were measured. In a subset of both groups, kidney function was estimated by GFRCKD-EPI CysC and uACR, and DKD risk defined by uACR tertiles. Youth with type 1 diabetes had higher sAF and BMI, and were taller than controls. For sAF, 13.6% of variance was explained by diabetes duration, height and BMI (Pmodel = 1.5 × 10-12). In the sub-set examining kidney function, eGFR and sAF were higher in type 1 diabetes versus controls. eGFR and sAF predicted 24.5% of variance in DKD risk (Pmodel = 2.2 × 10-9), which increased with diabetes duration (51%; Pmodel < 2.2 × 10-16) and random blood glucose concentrations (56%; Pmodel < 2.2 × 10-16). HbA1C and circulating fructosamine albumin were higher in individuals with type 1 diabetes at high versus low DKD risk. eGFR was independently associated with DKD risk in all models. Higher eGFR and longer diabetes duration are associated with DKD risk in youth with type 1 diabetes. sAF, circulating AGEs, and urinary AGEs were not independent predictors of DKD risk. Changes in eGFR should be monitored early, in addition to uACR, for determining DKD risk in type 1 diabetes.
DOI: 10.1038/s41598-021-88786-4
Journal: Scientific Reports
PubMed URL: 33941808
Type: Journal Article
Appears in Collections:Journal articles

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