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Title: Circuit Survival during Continuous Venovenous Hemodialysis versus Continuous Venovenous Hemofiltration.
Austin Authors: Califano, Alfonso Maria;Bitker, Laurent;Baldwin, Ian C ;Fealy, Nigel G ;Bellomo, Rinaldo 
Affiliation: Department of Nephrology, Hospital del Mar, Barcelona, Spain
Intensive Care
Service de Médecine Intensive et Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France
Centre for Integrated Critical Care, The University of Melbourne, Melbourne, Victoria, Australia
Issue Date: 21-Feb-2020
Date: 2020-02-21
Publication information: Blood Purification 2020; 49(3): 281-288
Abstract: Continuous renal replacement therapy (CRRT) technique may affect circuit lifespan. A shorter circuit life may reduce CRRT efficacy and increase costs. In a before-and-after study, we compared circuit median survival time during continuous venovenous hemofiltration (CVVH) versus continuous venovenous hemodialysis (-CVVHD). We performed log-rank mixed effects univariate analysis and Cox mixed effect regression modeling to define predictors of circuit lifespan. We compared 197 -CVVHD and 97 CVVH circuits in 39 patients. There was no overall difference in circuit lifespan. When no anticoagulation was used, median circuit survival time was shorter for CVVH circuits (5 h, 95% CI 3-7 vs. 10 h, 95% CI 8-13, p < 0.01). Moreover, CVVHD, lower platelets levels, and longer activated partial thromboplastin time independently predicted longer circuit median survival time. CVVHD is associated with longer circuit median survival time than CVVH when no anticoagulation is used and is an independent predictor of circuit survival.
DOI: 10.1159/000504037
Journal: Blood Purification
PubMed URL: 32088713
Type: Journal Article
Subjects: Acute kidney injury
Circuit survival
Continuous renal replacement therapy
Continuous venovenous hemodialysis
Appears in Collections:Journal articles

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