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Title: There is detectable variation in the lipidomic profile between stable and progressive patients with idiopathic pulmonary fibrosis (IPF).
Austin Authors: Nambiar, Shabarinath;Clynick, Britt;How, Bong S;King, Adam;Walters, E Haydn;Goh, Nicole S L ;Corte, Tamera J;Trengove, Robert;Tan, Dino;Moodley, Yuben
Affiliation: Fiona Stanley Hospital, Murdoch, WA, Australia
Austin Health
Institute for Breathing and Sleep
University of Sydney, Camperdown, NSW, Australia
Royal Prince Alfred Hospital, Camperdown, NSW, Australia
School of Biomedical Science, University of Western Australia, Crawley, WA, Australia
Institute for Respiratory Health, Nedlands, WA, Australia
Separation Science and Metabolomics Laboratory, Murdoch University, Murdoch, WA, Australia
Metabolomics Australia, Murdoch University, Murdoch, WA, Australia
Alfred Hospital, Melbourne, VIC, Australia
University of Tasmania, Hobart, TAS, Australia
University of Melbourne, Parkville, VIC, Australia
Royal Hobart Hospital, Hobart, TAS, Australia
Scientific Operations, Waters Corporation, Stamford Avenue, Wilmslow, SK9 4AX, UK
Issue Date: 9-Apr-2021
Date: 2021-04-09
Publication information: Respiratory Research 2021; 22(1): 105
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis and progressive loss of lung function. The pathophysiological pathways involved in IPF are not well understood. Abnormal lipid metabolism has been described in various other chronic lung diseases including asthma and chronic obstructive pulmonary disease (COPD). However, its potential role in IPF pathogenesis remains unclear. In this study, we used ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) to characterize lipid changes in plasma derived from IPF patients with stable and progressive disease. We further applied a data-independent acquisition (DIA) technique called SONAR, to improve the specificity of lipid identification. Statistical modelling showed variable discrimination between the stable and progressive subjects, revealing differences in the detection of triglycerides (TG) and phosphatidylcholines (PC) between progressors and stable IPF groups, which was further confirmed by mass spectrometry imaging (MSI) in IPF tissue. This is the first study to characterise lipid metabolism between stable and progressive IPF, with results suggesting disparities in the circulating lipidome with disease progression.
DOI: 10.1186/s12931-021-01682-3
ORCID: 0000-0002-8777-6877
Journal: Respiratory Research
PubMed URL: 33836757
Type: Journal Article
Subjects: DIA
Appears in Collections:Journal articles

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