Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26177
Title: Safety and Long-Term Clinical Outcomes of Fractional Flow Reserve Guided Coronary Revascularisation.
Austin Authors: Scully, Timothy G;Toner, Liam ;Yeoh, Julian;Farouque, Omar ;Yudi, Matias B ;Horrigan, Mark ;Clark, David J 
Affiliation: Cardiology
University of Melbourne, Melbourne, Vic, Australia
Issue Date: Sep-2021
Date: 2021-03-26
Publication information: Heart, Lung & Circulation 2021; 30(9): 1343-1347
Abstract: Increasingly, fractional flow reserve (FFR) is employed to assess coronary artery stenoses although there is limited real world long-term outcome data with a recent report questioning its safety. This study aimed to assess the in-hospital complications and clinical outcomes up to 10 years after FFR-guided revascularisation at a tertiary Australian hospital. The cohort comprised 274 consecutive patients undergoing FFR from 2010 to 2015 with follow-up to 2020. In-hospital complications and long-term outcomes were compared between patients with FFR≤0.80 and FFR>0.80. Major adverse cardiac events (MACE) comprised cardiac death, myocardial infarction (MI) and target vessel revascularisation (TVR). The FFR was ≤0.80 in 166 and >0.80 in 108 patients. Stable coronary disease was present in 95%. Revascularisation was undertaken in 86.7% of the FFR≤0.80 group and in 2.8% of the group with an FFR>0.80. In-hospital adverse events were 3.3% with no pressure wire-related coronary dissection, stroke or death. At median follow-up of 5 years, patients with FFR≤0.80 and FFR>0.80 had a similar rate of cardiac death (2.6% versus 5.0%, p=0.335) and MI (2.6% versus 6.9%, p=0.154). In the FFR>0.80 group, MACE (17.8% v 7.9%; p=0.018) and TVR (12.9% v 5.3%; p=0.033) were significantly higher. This observational study highlights the safety and long-term effectiveness of FFR-guided coronary revascularisation in patients with predominantly stable disease.
URI: https://ahro.austin.org.au/austinjspui/handle/1/26177
DOI: 10.1016/j.hlc.2021.02.009
Journal: Heart, Lung & Circulation
PubMed URL: 33781698
Type: Journal Article
Subjects: Coronary artery disease
FFR
Fractional flow reserve
Appears in Collections:Journal articles

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