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Title: Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma.
Austin Authors: Al-Khan, Awf A;Al Balushi, Noora R;Richardson, Samantha J;Danks, Janine A
Affiliation: Medicine (University of Melbourne)
Department of Pathology, Sohar Hospital, Sohar, Oman
School of Science, RMIT University, Bundoora, VIC, Australia
School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia
Issue Date: Mar-2021
Date: 2021-03
Publication information: Frontiers in Veterinary Science 2021; 8: 637614
Abstract: Osteosarcoma (OS) is the most common primary bone tumor and originates from bone forming mesenchymal cells and primarily affects children and adolescents. The 5-year survival rate for OS is 60 to 65%, with little improvement in prognosis during the last four decades. Studies have demonstrated the evolving roles of parathyroid hormone-related protein (PTHrP) and its receptor (PTHR1) in bone formation, bone remodeling, regulation of calcium transport from blood to milk, regulation of maternal calcium transport to the fetus and reabsorption of calcium in kidneys. These two molecules also play critical roles in the development, progression and metastasis of several tumors such as breast cancer, lung carcinoma, chondrosarcoma, squamous cell carcinoma, melanoma and OS. The protein expression of both PTHrP and PTHR1 have been demonstrated in OS, and their functions and proposed signaling pathways have been investigated yet their roles in OS have not been fully elucidated. This review aims to discuss the latest research with PTHrP and PTHR1 in OS tumorigenesis and possible mechanistic pathways. This review is dedicated to Professor Michael Day who died in May 2020 and was a very generous collaborator.
DOI: 10.3389/fvets.2021.637614
Journal: Frontiers in Veterinary Science
PubMed URL: 33796580
ISSN: 2297-1769
Type: Journal Article
Subjects: canine
parathyroid hormone
parathyroid hormone related protein
prognostic factor
Appears in Collections:Journal articles

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