Please use this identifier to cite or link to this item:
Title: Current directions in biomarkers and endophenotypes for anorexia nervosa: A scoping review.
Austin Authors: Malcolm, Amy;Phillipou, Andrea 
Affiliation: Mental Health
Department of Mental Health, St Vincent's Hospital, Melbourne, Australia
Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Centre for Mental Health, Faculty of Health, Arts & Design, Swinburne University of Technology, Hawthorn, VIC, Australia
Issue Date: 6-Mar-2021 2021-03-06
Publication information: Journal of Psychiatric Research 2021; 137: 303-310
Abstract: There are currently no validated biomarkers for anorexia nervosa (AN), though recent literature suggests an increased research interest in this area. Biomarkers are objective, measurable indicators of illness that can be used to assist with diagnosis, risk assessment, and tracking of illness state. Related to biomarkers are endophenotypes, which are quantifiable phenomena that are distinct from symptoms and which link genes to manifest illness. In this scoping review, we sought to provide a summary of recent research conducted in the pursuit of biomarkers and endophenotypes for AN. The findings indicate that a number of possible biomarkers which can assess the presence or severity of AN independently of weight status, including psychophysical (e.g., eye-tracking) and biological (e.g., immune, endocrine, metabolomic, neurobiological) markers, are currently under investigation. However, this research is still in early phases and lacking in replication studies. Endophenotype research has largely been confined to the study of several neurocognitive features, with mixed evidence to support their classification as possible endophenotypes for the disorder. The study of biomarkers and endophenotypes in AN involves significant challenges due to confounding factors of illness-related sequalae, such as starvation. Future research in these areas must prioritise direct evaluation of the sensitivity, specificity and test-retest reliability of proposed biomarkers and enhanced control of confounding physical consequences of AN in the study of biomarkers and endophenotypes.
DOI: 10.1016/j.jpsychires.2021.02.063
Journal: Journal of Psychiatric Research
PubMed URL: 33735721
Type: Journal Article
Subjects: Anorexia nervosa
Eating disorders
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Jun 6, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.