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Title: EXPRESS: International Stroke Genetics Consortium Recommendations for Studies of Genetics of Stroke Outcome and Recovery.
Austin Authors: Lindgren, Arne;Braun, Robynne;Majersik, Jennifer J;Clatworthy, Philip;Mainali, Shraddha;Derdeyn, Colin P;Maguire, Jane Margaret;Jern, Christina;Rosand, Jonathan;Cole, John W;Lee, Jin-Moo;Khatri, Pooja;Nyquist, Paul A;Debette, Stà Phanie;Keat Wei, Loo;Rundek, Tatjana;Leifer, Dana;Thijs, Vincent N ;Lemmens, Robin;Heitsch, Laura;Prasad, Kameshwar;Jimenez-Conde, Jordi;Dichgans, Martin;Rost, Natalia S;Cramer, Steven C;Bernhardt, Julie;Worrall, Bradford B;Cadenas, Israel
Affiliation: Lund University, Department of Clinical Sciences Lund, Department of Neurology, SkÃ¥ne University Hospital, Lund, Sweden
Klinikum Grosshadern, University of Munich, Neurology, Klinikum der Universität München, Munich, Germany
The Florey Institute of Neuroscience and Mental Health
Johns Hopkins School of Medicine, Neurology, Baltimore, Maryland, United States
Johns Hopkins Medical Institution, Neurology, Baltimore, Maryland, United States
University Hospitals Leuven, Neurology, Leuven, Belgium..
KULeuven, Experimental Neurology, Leuven, Belgium
University of Maryland Baltimore, Baltimore, Maryland, United States
University of Technology Sydney Faculty of Health, Faculty of Health, Jones street, Sydney, New South Wales, Australia
University of Utah, Department of Neurology, Salt Lake City, Utah, United States
Bristol Medical School, Department of Neurology, North Bristol NHS Trust and Bristol Medical School, Bristol, Bristol, United Kingdom of Great Britain and Northern Ireland
The Ohio State University, Department of Neurology, Division of Stroke and Neurocritical Care, Columbus, Ohio, United States
Univeristy of Iowa, Radiology, Iowa City, United States
Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Department of Medical and Clinical Genetics, Gothenburg, Sweden
Massachusett General Hospital, Neurology, Center for Human Genetic Research, 185 Cambridge Street, CPZN-6818, Boston, Massachusetts, United States
University of Maryland School of Medicine, Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, Maryland, United States
Washington University in Saint Louis School of Medicine, Department of Neurology, and the Hope Center for Neurological disorders, Saint Louis, Missouri, United States
University of Cincinnati Health, Neurology, Cincinnati, Ohio, United States
Inserm U708 - University of Versailles-St-Quentin, Neurology, 146 rue leo saignat, bordeaux, France
Universiti Sains Malaysia, Human Genome Centre, School of Medical Sciences, USM, Kubang Kerian, Kelantan, Malaysia
University of Miami Miller School of Medicine, Department of Neurology and Evelyn F. McKnight Brain Institute, Miami, Florida, United States
Weill Cornell Medical College, Department of Neurology, New York, New York, United States
Washington University School of Medicine in Saint Louis, Department of Neurology, St Louis, Missouri, United States
All India Institute of Medical Sciences New Delhi, India-110029, Professor and Head, Department of Neurology, New Delhi, India
Institut Hospital del Mar dâInvestigacions Mèdiques, Neurology, Barcelona, Spain
Massachusetts General Hospital, Neurology, 175 Cambridge Street, Suite 300, Boston, Massachusetts, United States
University of California Los Angeles, Department of Neurology, Los Angeles, California, United States
University of Virginia, Neurology, Charlottesville, Virginia, United States
Hospital de la Santa Creu i Sant Pau Institut de Recerca, Stroke pharmacogenomics and genetics lab, Barcelona, Catalunya, Spain
Issue Date: 19-Mar-2021
Date: 2021-03-19
Publication information: International Journal of Stroke 2021; online first: 19 March
Abstract: Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.
DOI: 10.1177/17474930211007288
ORCID: 0000-0003-1942-7330
Journal: International Journal of Stroke
PubMed URL: 33739214
Type: Journal Article
Subjects: Data collection
Ischaemic Stroke
Appears in Collections:Journal articles

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