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Title: Conceptual advances and evolving terminology in acute kidney disease.
Austin Authors: Kellum, John A;Ronco, Claudio;Bellomo, Rinaldo 
Affiliation: Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Intensive Care
Department of Critical Care, The University of Melbourne, Melbourne, Australia
Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia
Department of Nephrology, San Bortolo Hospital, Vicenza, Italy
Department of Medicine, University of Padova, Padova, Italy
International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy
Issue Date: Jul-2021
Date: 2021-03-12
Publication information: Nature Reviews. Nephrology 2021; 17(7): 493-502
Abstract: Over the past decade, new insights into epidemiology, pathophysiology and biomarkers have modified our understanding of acute kidney dysfunction and damage, and their association with subsequent chronic kidney disease. The concept of acute kidney injury (AKI), which has relied on established but nonetheless flawed biomarkers of solute clearance (serum creatinine levels and urinary output), has been challenged by the identification of novel biomarkers of tubular stress and/or damage. The expression of some of these novel biomarkers precedes changes in conventional biomarkers or can increase their predictive power, and might therefore enhance the clinical accuracy of the definition of AKI. In addition, the need to consider AKI recurrence, duration and progression to chronic kidney disease within the clinical and epidemiological framework of AKI led to the emergence of the concept of acute kidney disease. New definitions of acute syndromes of kidney impairment and injury are needed.
DOI: 10.1038/s41581-021-00410-w
ORCID: 0000-0003-1995-2653
Journal: Nature reviews. Nephrology
PubMed URL: 33712812
Type: Journal Article
Subjects: Acute kidney disease
Appears in Collections:Journal articles

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