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dc.contributor.authorKellum, John A-
dc.contributor.authorRonco, Claudio-
dc.contributor.authorBellomo, Rinaldo-
dc.identifier.citationNature Reviews. Nephrology 2021; 17(7): 493-502en
dc.description.abstractOver the past decade, new insights into epidemiology, pathophysiology and biomarkers have modified our understanding of acute kidney dysfunction and damage, and their association with subsequent chronic kidney disease. The concept of acute kidney injury (AKI), which has relied on established but nonetheless flawed biomarkers of solute clearance (serum creatinine levels and urinary output), has been challenged by the identification of novel biomarkers of tubular stress and/or damage. The expression of some of these novel biomarkers precedes changes in conventional biomarkers or can increase their predictive power, and might therefore enhance the clinical accuracy of the definition of AKI. In addition, the need to consider AKI recurrence, duration and progression to chronic kidney disease within the clinical and epidemiological framework of AKI led to the emergence of the concept of acute kidney disease. New definitions of acute syndromes of kidney impairment and injury are needed.en
dc.subjectAcute kidney diseaseen
dc.titleConceptual advances and evolving terminology in acute kidney disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleNature reviews. Nephrologyen
dc.identifier.affiliationCenter for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USAen
dc.identifier.affiliationIntensive Careen
dc.identifier.affiliationDepartment of Critical Care, The University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Royal Melbourne Hospital, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Nephrology, San Bortolo Hospital, Vicenza, Italyen
dc.identifier.affiliationDepartment of Medicine, University of Padova, Padova, Italyen
dc.identifier.affiliationInternational Renal Research Institute of Vicenza (IRRIV), Vicenza, Italyen
dc.identifier.pubmedid33712812-, Rinaldo
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en- Care- Analytics Research and Evaluation (DARE) Centre-
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