Therapeutic Targeting of the Tumour Microenvironment in Metastatic Colorectal Cancer.

2021-02-19

Dmello, Rhynelle S

To, Sarah Q

Chand, Ashwini L

cytokines

immunotherapy

inflammation

metastatic colorectal cancer

targeted therapy

tumour heterogeneity

tumour microenvironment

Journal Article

0000-0002-1245-729X

10.3390/ijms22042067

Liver metastasis is the primary contributor to the death of patients with colorectal cancer. Despite the overall success of current treatments including targeted therapy, chemotherapy, and immunotherapy combinations in colorectal cancer patients, the prognosis of patients with liver metastasis remains poor. Recent studies have highlighted the importance of the tumour microenvironment and the crosstalk within that determines the fate of circulating tumour cells in distant organs. Understanding the interactions between liver resident cells and tumour cells colonising the liver opens new therapeutic windows for the successful treatment of metastatic colorectal cancer. Here we discuss critical cellular interactions within the tumour microenvironment in primary tumours and in liver metastases that highlight potential therapeutic targets. We also discuss recent therapeutic advances for the treatment of metastatic colorectal cancer.

link

International Journal of Molecular Sciences 2021; 22(4): 2067

International Journal of Molecular Sciences