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Title: Exercise physiology in cirrhosis and the potential benefits of exercise interventions - a review.
Austin Authors: West, Jack;Gow, Paul J ;Testro, Adam G ;Chapman, Brooke ;Sinclair, Marie 
Affiliation: Medicine (University of Melbourne)
Victorian Liver Transplant Unit
Issue Date: 27-Feb-2021
Date: 2021-02-27
Publication information: Journal of Gastroenterology and Hepatology 2021; 36(10): 2687-2705
Abstract: Reduction in muscle mass is a highly prevalent phenomenon in cirrhosis and is now well-documented to be associated with significant morbidity and mortality. Research into muscle loss in cirrhosis remains limited by an ongoing poor understanding of its relationship with muscle function, physical activity and aerobic capacity. Alterations in exercise physiology have been documented in studies of individuals with cirrhosis that provide important information on physical function that is not captured by simple quantification of muscle mass. Despite expert consensus recommending regular exercise in end-stage liver disease to maintain muscle mass and function, there is little evidence guiding clinicians as to which form of exercise or delivery mechanism is most effective. It also remains unproven whether any specific intervention can alter clinically relevant outcomes. This review article summaries the available literature regarding the changes in exercise physiology observed in cirrhosis, the associated impact on physical capacity and the results of existing trials that examine the potential benefits of exercise delivery in patients with cirrhosis, particularly pertaining to their impact on exercise physiology.
DOI: 10.1111/jgh.15474
ORCID: 0000-0003-2732-8826
Journal: Journal of Gastroenterology and Hepatology
PubMed URL: 33638197
Type: Journal Article
Subjects: cirrhosis
Appears in Collections:Journal articles

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