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Title: Speech, Language and Oromotor Skills in Patients with Polymicrogyria.
Austin Authors: Braden MSpPath, Ruth O;Boyce, Jessica O;Stutterd, Chloe A ;Pope, Kate;Goel, Himanshu;Leventer, Richard J;Scheffer, Ingrid E ;Morgan, Angela T
Affiliation: Murdoch Children's Research Institute, Parkville, Victoria 3052, Australia
Department of Audiology and Speech Pathology, University of Melbourne, Parkville, Victoria 3052, Australia
The Royal Children's Hospital, Parkville, Victoria 3052, Australia
Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia
Austin Health
Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia
Victorian Clinical Genetics Service, Parkville, Victoria 3052, Australia
Hunter Genetics, John Hunter Hospital, New Lambton Heights, New South Wales 2305, Australia
Murdoch Children's Research Institute, Parkville, Victoria 3052, Australia
Issue Date: 5-Apr-2021
Date: 2021-02-15
Publication information: Neurology 2021; 96(14): e1898-e1912
Abstract: To determine whether specific speech, language and oromotor profiles are associated with different patterns of polymicrogyria (PMG), we assessed 52 patients with PMG using a battery of standardised tests and correlated findings with topography and severity of PMG. Patients were identified via clinical research databases and invited to participate, irrespective of cognitive and verbal language abilities. We conducted standardised assessments of speech, oromotor structure and function, language and nonverbal IQ. Data were analysed according to normative assessment data and descriptive statistics. We conducted a correlation analysis between topographic pattern and speech and language findings. 52 patients (33 males, 63%) were studied at an average age of 12.7 years (range 2.5-36 years). All patients had dysarthria, which ranged from mild impairment to anarthria. Developmental speech errors (articulation and phonology), oral motor structure and function deficits and language disorder were frequent. 23/29 (79%) had cognitive abilities in the low average to extremely low range. In the perisylvian PMG group (36/52), speech, everyday language and oral motor impairments were more severe, compared to generalised (1 patient), frontal (3), PMG with periventricular nodular heterotopia (3), parasagittal parieto-occipital (1), mesial occipital (1) and other (7) patterns. Dysarthria is a core feature of PMG, often accompanied by receptive and expressive language impairments. These features are associated with all PMG distribution patterns and more severe in individuals with bilateral PMG, particularly in the perisylvian region.
DOI: 10.1212/WNL.0000000000011698
ORCID: 0000-0001-7730-1205
Journal: Neurology
PubMed URL: 33589534
Type: Journal Article
Appears in Collections:Journal articles

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