Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25847
Title: Integrated immune dynamics define correlates of COVID-19 severity and antibody responses.
Austin Authors: Koutsakos, Marios;Rowntree, Louise C;Hensen, Luca;Chua, Brendon Y;van de Sandt, Carolien E;Habel, Jennifer R;Zhang, Wuji;Jia, Xiaoxiao;Kedzierski, Lukasz;Ashhurst, Thomas M;Putri, Givanna H;Marsh-Wakefield, Felix;Read, Mark N;Edwards, Davis N;Clemens, E Bridie;Wong, Chinn Yi;Mordant, Francesca L;Juno, Jennifer A;Amanat, Fatima;Audsley, Jennifer;Holmes, Natasha E ;Gordon, Claire L ;Smibert, Olivia C ;Trubiano, Jason A ;Hughes, Carly M;Catton, Mike;Denholm, Justin T;Tong, Steven Yc;Doolan, Denise L;Kotsimbos, Tom C;Jackson, David C;Krammer, Florian;Godfrey, Dale I;Chung, Amy W;King, Nicholas Jc;Lewin, Sharon R;Wheatley, Adam K;Kent, Stephen J;Subbarao, Kanta;McMahon, James;Thevarajan, Irani;Nguyen, Thi Ho;Cheng, Allen C;Kedzierska, Katherine
Affiliation: World Health Organisation Collaborating Centre for Reference and Research on Influenza, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574 USA
Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC, Australia
Viral Immunopathology Laboratory, Discipline of Pathology, School of Medical Sciences, University of Sydney, NSW, Australia
Sydney Nano, University of Sydney, NSW 2006, Australia
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Charles Perkins Centre, University of Sydney, NSW, Australia
School of Computer Science, University of Sydney, NSW, Australia
The Westmead Initiative, University of Sydney, NSW, Australia
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, NSW, Australia
Vascular Immunology Unit, Discipline of Pathology, School of Medical Sciences, University of Sydney, NSW, Australia
Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, NSW, Australia
Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, NSW, Australia
Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia
Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC, Australia
Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, The Netherlands..
Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan..
Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC, Australia
Australian Research Council Centre of Excellence for Advanced Molecular Imaging at University of Melbourne, Melbourne, VIC, Australia
Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, Australia
Department of Allergy, Immunology, and Respiratory Medicine, Alfred Hospital, Melbourne, VIC, Australia
Victorian Infectious Diseases Services, Royal Melbourne Hospital and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC, Australia
Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia
Infectious Diseases
Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC, Australia
National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia
Department of Medicine and Radiology, University of Melbourne, Parkville VIC, Australia
Data Analytics Research and Evaluation (DARE) Centre
Centre for Antibiotic Allergy and Research
Melbourne Sexual Health Centre, Infectious Diseases Department, Alfred Health, Central Clinical School, Monash University, Melbourne, Australia
Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, VIC, Australia
Centre for Molecular Therapeutics, Australian Institute of Tropical Health & Medicine, James Cook University, Cairns, QLD, Australia
Monash Infectious Diseases, Monash Medical Centre, Monash Health, Melbourne, VIC, Australia
Medicine (University of Melbourne)
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia
Issue Date: 5-Feb-2021
metadata.dc.date: 2021-02-05
Publication information: Cell Reports. Medicine 2021; online first: 5 February
Abstract: SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill-defined. We analysed 85 SARS-CoV-2-infected individuals at acute and/or convalescent timepoints, up to 102 days post-symptom onset, quantifying 184 immunological parameters. Acute COVID-19 presented with high levels of IL-6, IL-18 and IL-10 and broad activation marked by upregulation of CD38 on innate and adaptive lymphocytes and myeloid cells. Importantly, activated CXCR3+cTFH1 cells in acute COVID-19 significantly correlate with and predict antibody levels and their avidity at convalescence as well as acute neutralisation activity. Strikingly, intensive care unit (ICU) patients with severe COVID-19 display higher levels of soluble IL-6, IL-6R, IL-18, and hyperactivation of innate, adaptive and myeloid compartments than patients with moderate disease. Our analyses provide a comprehensive map of longitudinal immunological responses in COVID-19 patients and integrate key cellular pathways of complex immune networks underpinning severe COVID-19, providing important insights into potential biomarkers and immunotherapies.
URI: https://ahro.austin.org.au/austinjspui/handle/1/25847
DOI: 10.1016/j.xcrm.2021.100208
PubMed URL: 33564749
Type: Journal Article
Appears in Collections:Journal articles

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