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https://ahro.austin.org.au/austinjspui/handle/1/25847| Title: | Integrated immune dynamics define correlates of COVID-19 severity and antibody responses. | Austin Authors: | Koutsakos, Marios;Rowntree, Louise C;Hensen, Luca;Chua, Brendon Y;van de Sandt, Carolien E;Habel, Jennifer R;Zhang, Wuji;Jia, Xiaoxiao;Kedzierski, Lukasz;Ashhurst, Thomas M;Putri, Givanna H;Marsh-Wakefield, Felix;Read, Mark N;Edwards, Davis N;Clemens, E Bridie;Wong, Chinn Yi;Mordant, Francesca L;Juno, Jennifer A;Amanat, Fatima;Audsley, Jennifer;Holmes, Natasha E ;Gordon, Claire L ;Smibert, Olivia C ;Trubiano, Jason ;Hughes, Carly M;Catton, Mike;Denholm, Justin T;Tong, Steven Yc;Doolan, Denise L;Kotsimbos, Tom C;Jackson, David C;Krammer, Florian;Godfrey, Dale I;Chung, Amy W;King, Nicholas Jc;Lewin, Sharon R;Wheatley, Adam K;Kent, Stephen J;Subbarao, Kanta;McMahon, James;Thevarajan, Irani;Nguyen, Thi Ho;Cheng, Allen C;Kedzierska, Katherine | Affiliation: | Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, The Netherlands World Health Organisation Collaborating Centre for Reference and Research on Influenza, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574 USA Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC, Australia Viral Immunopathology Laboratory, Discipline of Pathology, School of Medical Sciences, University of Sydney, NSW, Australia Sydney Nano, University of Sydney, NSW 2006, Australia Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA Charles Perkins Centre, University of Sydney, NSW, Australia School of Computer Science, University of Sydney, NSW, Australia The Westmead Initiative, University of Sydney, NSW, Australia School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, NSW, Australia Vascular Immunology Unit, Discipline of Pathology, School of Medical Sciences, University of Sydney, NSW, Australia Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, NSW, Australia Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, NSW, Australia Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC, Australia Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC, Australia Australian Research Council Centre of Excellence for Advanced Molecular Imaging at University of Melbourne, Melbourne, VIC, Australia Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, Australia Department of Allergy, Immunology, and Respiratory Medicine, Alfred Hospital, Melbourne, VIC, Australia Victorian Infectious Diseases Services, Royal Melbourne Hospital and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC, Australia Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia Infectious Diseases Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC, Australia National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia Department of Medicine and Radiology, University of Melbourne, Parkville VIC, Australia Data Analytics Research and Evaluation (DARE) Centre Centre for Antibiotic Allergy and Research Melbourne Sexual Health Centre, Infectious Diseases Department, Alfred Health, Central Clinical School, Monash University, Melbourne, Australia Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, VIC, Australia Centre for Molecular Therapeutics, Australian Institute of Tropical Health & Medicine, James Cook University, Cairns, QLD, Australia Monash Infectious Diseases, Monash Medical Centre, Monash Health, Melbourne, VIC, Australia Medicine (University of Melbourne) School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia |
Issue Date: | 5-Feb-2021 | Date: | 2021-02-05 | Publication information: | Cell Reports. Medicine 2021; online first: 5 February | Abstract: | SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill-defined. We analysed 85 SARS-CoV-2-infected individuals at acute and/or convalescent timepoints, up to 102 days post-symptom onset, quantifying 184 immunological parameters. Acute COVID-19 presented with high levels of IL-6, IL-18 and IL-10 and broad activation marked by upregulation of CD38 on innate and adaptive lymphocytes and myeloid cells. Importantly, activated CXCR3+cTFH1 cells in acute COVID-19 significantly correlate with and predict antibody levels and their avidity at convalescence as well as acute neutralisation activity. Strikingly, intensive care unit (ICU) patients with severe COVID-19 display higher levels of soluble IL-6, IL-6R, IL-18, and hyperactivation of innate, adaptive and myeloid compartments than patients with moderate disease. Our analyses provide a comprehensive map of longitudinal immunological responses in COVID-19 patients and integrate key cellular pathways of complex immune networks underpinning severe COVID-19, providing important insights into potential biomarkers and immunotherapies. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/25847 | DOI: | 10.1016/j.xcrm.2021.100208 | Journal: | Cell Reports. Medicine | PubMed URL: | 33564749 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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