Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25831
Title: Climate change and epilepsy: Insights from clinical and basic science studies.
Austin Authors: Gulcebi, Medine I;Bartolini, Emanuele;Lee, Omay;Lisgaras, Christos Panagiotis;Onat, Filiz;Mifsud, Janet;Striano, Pasquale;Vezzani, Annamaria;Hildebrand, Michael S ;Jimenez-Jimenez, Diego;Junck, Larry;Lewis-Smith, David;Scheffer, Ingrid E ;Thijs, Roland D;Zuberi, Sameer M;Blenkinsop, Stephen;Fowler, Hayley J;Foley, Aideen;Sisodiya, Sanjay M
Affiliation: Department of Medical Pharmacology, Marmara University, School of Medicine, Istanbul, Turkey
Department of Neurology and Clinical Neurophysiology, St. George's University Hospitals NHS Foundation Trust, London, UK
The Nathan S. Kline Institute for Psychiatric Research, Center for Dementia Research, 140 Old Orangeburg Rd., Orangeburg, NY 10962, USA
USL Centro Toscana, Neurology Unit, Nuovo Ospedale Santo Stefano, Via Suor Niccolina Infermiera 20, 59100 Prato, Italy
New York University Langone Health, 100 First Ave., New York, NY 10016, USA
Department of Medical Pharmacology, Marmara University School of Medicine, Istanbul, Turkey
Department of Medical Pharmacology, Acibadem University School of Medicine, Istanbul, Turkey
Department of Clinical Pharmacology and Therapeutics, University of Malta, Msida MSD2040, Malta
Paediatric Neurology and Muscular Diseases Unit, DINOGMI-Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, IRCCS "Giannina Gaslini" Institute, Genova, Italy
Laboratory of Experimental Neurology, Department of Neuroscience, IRCCS 'Mario Negri' Institute for Pharmacological Research, Milan, Italy
Murdoch Children's Research Institute, Melbourne, Victoria, Australia
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK and Chalfont Centre for Epilepsy, Bucks, UK
Department of Neurology, University of Michigan, Ann Arbor, MI, USA
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Royal Children's Hospital, and Murdoch Children's Research Institute, Melbourne, Australia
Department of Neurology, Leiden University Medical Centre (LUMC), PO Box 9600, 2300 RC Leiden, the Netherlands
Paediatric Neurosciences Research Group, Royal Hospital for Children & Institute of Health & Wellbeing, University of Glasgow, Fraser of Allander Neurosciences Unit, Royal Hospital for Children, UK
School of Engineering, Newcastle University, Newcastle upon Tyne, UK
Centre for Earth Systems Engineering Research, School of Engineering, Newcastle University, UK
Department of Geography, Birkbeck College University of London, London, UK
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK
General Medicine
Medicine (University of Melbourne)
The Florey Institute of Neuroscience and Mental Health
Issue Date: Mar-2021
Date: 2021-02-09
Publication information: Epilepsy & Behavior : E&B 2021; 116: 107791
Abstract: Climate change is with us. As professionals who place value on evidence-based practice, climate change is something we cannot ignore. The current pandemic of the novel coronavirus, SARS-CoV-2, has demonstrated how global crises can arise suddenly and have a significant impact on public health. Global warming, a chronic process punctuated by acute episodes of extreme weather events, is an insidious global health crisis needing at least as much attention. Many neurological diseases are complex chronic conditions influenced at many levels by changes in the environment. This review aimed to collate and evaluate reports from clinical and basic science about the relationship between climate change and epilepsy. The keywords climate change, seasonal variation, temperature, humidity, thermoregulation, biorhythm, gene, circadian rhythm, heat, and weather were used to search the published evidence. A number of climatic variables are associated with increased seizure frequency in people with epilepsy. Climate change-induced increase in seizure precipitants such as fevers, stress, and sleep deprivation (e.g. as a result of more frequent extreme weather events) or vector-borne infections may trigger or exacerbate seizures, lead to deterioration of seizure control, and affect neurological, cerebrovascular, or cardiovascular comorbidities and risk of sudden unexpected death in epilepsy. Risks are likely to be modified by many factors, ranging from individual genetic variation and temperature-dependent channel function, to housing quality and global supply chains. According to the results of the limited number of experimental studies with animal models of seizures or epilepsy, different seizure types appear to have distinct susceptibility to seasonal influences. Increased body temperature, whether in the context of fever or not, has a critical role in seizure threshold and seizure-related brain damage. Links between climate change and epilepsy are likely to be multifactorial, complex, and often indirect, which makes predictions difficult. We need more data on possible climate-driven altered risks for seizures, epilepsy, and epileptogenesis, to identify underlying mechanisms at systems, cellular, and molecular levels for better understanding of the impact of climate change on epilepsy. Further focussed data would help us to develop evidence for mitigation methods to do more to protect people with epilepsy from the effects of climate change.
URI: https://ahro.austin.org.au/austinjspui/handle/1/25831
DOI: 10.1016/j.yebeh.2021.107791
Journal: Epilepsy & Behavior : E&B
PubMed URL: 33578223
Type: Journal Article
Subjects: Emergency
Extreme weather events
Global warming
Public health
Seizure
Temperature
Appears in Collections:Journal articles

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