Greater preference for eveningness is associated with negative symptoms in an ultra-high risk for psychosis sample.

2021

Shetty, Jashmina J

Nicholas, Christian

Nelson, Barnaby

McGorry, Patrick D

Lavoie, Suzie

Markulev, Connie

Schäfer, Miriam R

Thompson, Andrew

Yuen, Hok Pan

Yung, Alison R

Nieman, Dorien H

de Haan, Lieuwe

Amminger, G Paul

Hartmann, Jessica A

chronotype

negative symptoms

psychosis

sleep

ultra-high risk

Journal Article

0000-0003-3190-1859

0000-0001-8969-4595

10.1111/eip.13112

Investigating biological processes in at-risk individuals may help elucidate the aetiological mechanisms underlying psychosis development, refine prediction models and improve intervention strategies. This study examined the associations between sleep disturbances, chronotype, depressive and psychotic symptoms in individuals at ultra-high risk for psychosis. A sample of 81 ultra-high risk patients completed clinical interviews and self-report assessments of chronotype and sleep during the Neurapro clinical trial. Mixed regression was used to investigate the cross-sectional associations between symptoms and sleep disturbances/chronotype. Sleep disturbances were significantly associated with increased depressive and attenuated positive psychotic symptoms. Greater preference for eveningness was significantly associated with increased negative symptoms, but not with depressive or attenuated positive psychotic symptoms. Sleep disturbances and chronotype may impact the emerging psychopathology experienced by ultra-high risk individuals. Further, the preliminary relationship observed between greater preference for eveningness and negative symptoms offers a unique opportunity to treat negative symptoms through chronobiological approaches.

link

Early intervention in psychiatry 2021; 15(6): 1793-1798

Early Intervention in Psychiatry