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https://ahro.austin.org.au/austinjspui/handle/1/25739| Title: | Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement. | Austin Authors: | Narayanasamy, Shanti;Nation, Roger L;Mahony, Andrew A ;Grayson, M Lindsay ;Kwong, Jason C ;Sherry, Norelle L ;Khumra, Sharmila ;Ellis, Andrew G ;Frauman, Albert G ;Holmes, Natasha E | Affiliation: | Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia Department of Medicine, University of Melbourne, Melbourne, Australia Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne at the Doherty Institute for Infection & Immunity, Melbourne, Australia Clinical Pharmacology and Therapeutics Pharmacy Infectious Diseases |
Issue Date: | Jan-2021 | Date: | 2020-11-26 | Publication information: | Open Forum Infectious Diseases 2021; 8(1): ofaa572 | Abstract: | We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/25739 | DOI: | 10.1093/ofid/ofaa572 | ORCID: | 0000-0002-6667-2868 0000-0003-1492-8590 |
Journal: | Open Forum Infectious Diseases | PubMed URL: | 33511225 | ISSN: | 2328-8957 | Type: | Journal Article | Subjects: | XDR gram-negative colistin fosfomycin osteomyelitis therapeutic drug monitoring |
| Appears in Collections: | Journal articles |
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