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Title: Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement.
Austin Authors: Narayanasamy, Shanti;Nation, Roger L;Mahony, Andrew A ;Grayson, M Lindsay ;Kwong, Jason C ;Sherry, Norelle L ;Khumra, Sharmila ;Ellis, Andrew G ;Frauman, Albert G ;Holmes, Natasha E 
Affiliation: Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
Department of Medicine, University of Melbourne, Melbourne, Australia
Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne at the Doherty Institute for Infection & Immunity, Melbourne, Australia
Clinical Pharmacology and Therapeutics
Infectious Diseases
Issue Date: Jan-2021
Date: 2020-11-26
Publication information: Open Forum Infectious Diseases 2021; 8(1): ofaa572
Abstract: We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.
DOI: 10.1093/ofid/ofaa572
ORCID: 0000-0002-6667-2868
Journal: Open Forum Infectious Diseases
PubMed URL: 33511225
ISSN: 2328-8957
Type: Journal Article
Subjects: XDR gram-negative
therapeutic drug monitoring
Appears in Collections:Journal articles

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