Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25697
Title: Evaluation of intravenous to oral antimicrobial switch at a hospital with a tightly regulated antimicrobial stewardship program.
Austin Authors: Khumra, Sharmila ;Mahony, Andrew A ;Bergen, Phillip J;Elliott, Rohan A 
Affiliation: Department of Medicine, Melbourne University, Melbourne, Victoria, Australia
Pharmacy
Infectious Diseases
Centre for Medicines Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia
Department of Microbiology, Monash University, Melbourne, Victoria, Australia
Issue Date: Aug-2021
Date: 2021-01-15
Publication information: British Journal of Clinical Pharmacology 2021; 87(8): 3354-3358
Abstract: Timely intravenous (IV) to oral antimicrobial switch (IV-oral-switch) is a key antimicrobial stewardship (AMS) strategy. We aimed to explore concordance with IV-oral-switch guidelines in the context of a long-standing, tightly regulated AMS program. Data was retrospectively collected for 107 adult general medical and surgical patients in an Australian hospital. Median duration of IV antimicrobial courses before switching to oral therapy was 3 days (interquartile range [IQR] 2.25-5.00). Timely IV-oral-switch occurred in 57% (n = 61) of patients. The median delay to switching was 0 days (IQR 0 to 1.25). In most courses (92/106, 86.8%), the choice of oral alternative after switching was appropriate. In 45% (47/105) of courses, total duration of therapy (IV plus oral) exceeded the recommended duration by >1.0 day. Excessive IV antimicrobial duration was uncommon at a hospital with a tightly regulated AMS program. Total duration of therapy was identified as an AMS target for improvement.
URI: https://ahro.austin.org.au/austinjspui/handle/1/25697
DOI: 10.1111/bcp.14734
ORCID: 0000-0002-3499-8652
0000-0002-7750-9724
Journal: British Journal of Clinical Pharmacology
PubMed URL: 33450086
Type: Journal Article
Subjects: antimicrobial stewardship
antimicrobials
guidelines
hospital
preauthoriziation
switch therapy
Appears in Collections:Journal articles

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