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Title: Feasibility of an online cognitive rehabilitation program in patients with a haematological malignancy undergoing autologous stem cell transplantation.
Austin Authors: Ku, Matthew;Gates, Priscilla ;Renehan, Steffi
Affiliation: Olivia Newton-John Cancer Wellness and Research Centre
Dept of Clinical Haematology, Consultant Haematologist, St Vincent's Hospital. Melbourne. Victoria. 3065
Senior Research Fellow, University of Melbourne, Parkville, Victoria
Issue Date: Oct-2021
Date: 2021-01-19
Publication information: Internal Medicine Journal 2021; 51(10): 1665-1672
Abstract: Chemotherapy related cognitive impairment (CRCI) is a known adverse event that can impact cancer survivors, resulting in long-standing effect on quality of life (QOL) and activities of daily living (ADL). Currently, there is limited knowledge regarding the etiology and therapy for CRCI. Although CRCI following autologous stem cell transplantation (AuSCT) is emerging as a potentially significant concern for patients with underlying haematological malignancies, it is an area that requires further research. This pilot study assessed 1) the prevalence of CRCI in patients with haematological malignancies both pre-AuSCT and post-AuSCT, 2) the feasibility of a cognitive rehabilitation program (CRP) in survivorship care post-AuSCT. Over a 12 month period, consecutive patients planned for AuSCT were approached for the study. Enrolled patients were administered a nine-week course of CRP, commencing day 40±5 post-AuSCT. Participants were evaluated using a neuropsychological tool and validated questionnaires at baseline, pre-CRP (day 40±5 post-AuSCT), post-CRP and six months post-CRP. Thirty-two patients were enrolled. The mean age was 59 years (SD=11.5), 23 (72%) were male and 18 (56%) had multiple myeloma. Participants reported high satisfaction using the CRP, and most devoted significant amount of time as requested. While there appeared to be a low incidence of significant CRCI in our patient population, the incorporation of CRP in survivorship care appeared to be feasible. A larger randomised study examining the efficacy of CRP should be further explored. This article is protected by copyright. All rights reserved.
DOI: 10.1111/imj.15204
ORCID: 0000-0002-9289-1335
Journal: Internal Medicine Journal
PubMed URL: 33465274
Type: Journal Article
Subjects: Cognitive rehabilitation
cognitive impairment
haematological malignancy
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