A multi-institutional outbreak of New Delhi metallo-β-lactamase-producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene.

Solter, Ester; Kwong, Jason C; Walton, Aaron; Sherry, Norelle L; Howden, Benjamin P; Grayson, M Lindsay; Schwartz, David; Temkin, Elizabeth; Frenk, Sammy; Carmeli, Yehuda; Schwaber, Mitchell J

doi:10.1017/ice.2020.1361

Title

A multi-institutional outbreak of New Delhi metallo-β-lactamase-producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene.

Publication Date

2021-09

Author(s)

Solter, Ester

Kwong, Jason C

Walton, Aaron

Sherry, Norelle L

Howden, Benjamin P

Grayson, M Lindsay

Schwartz, David

Temkin, Elizabeth

Frenk, Sammy

Carmeli, Yehuda

Schwaber, Mitchell J

Type of document

Journal Article

DOI

10.1017/ice.2020.1361

Abstract

We characterized 57 isolates from a 2-phase clonal outbreak of New Delhi metallo-β-lactamase-producing Eschericha coli, involving 9 Israeli hospitals; all but 1 isolate belonged to sequence-type (ST) 410. Most isolates in the second phase harbored blaKPC-2 in addition to blaNDM-5. Genetic sequencing revealed most dual-carbapenemase-producing isolates to be monophyletically derived from a common ancestor.

Link

link

Citation

Infection Control and Hospital Epidemiology 2021; 42(9): 1124-1127

Jornal Title

Infection Control and Hospital Epidemiology

Austin Health

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