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Title: Gut Microbiome Composition Remains Stable in Individuals with Diabetes-Related Early to Late Stage Chronic Kidney Disease.
Austin Authors: Lecamwasam, Ashani ;Nelson, Tiffanie M;Rivera, Leni;Ekinci, Elif I ;Saffery, Richard;Dwyer, Karen M
Affiliation: Department of Medicine, University of Melbourne, Parkville, VIC 3010, Australia
School of Medicine, Faculty of Health, Deakin University, Geelong Waurn Ponds, VIC 3220, Australia
Department of Paediatrics, University of Melbourne, Parkville, VIC 3010, Australia
Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia
Epigenetics Research, Murdoch Children's Research Institute, Parkville, VIC 3052, Australia
Issue Date: 29-Dec-2020
Date: 2020-12-29
Publication information: Biomedicines 2020; 9(1): E19
Abstract: Background: Individuals with diabetes and chronic kidney disease display gut dysbiosis when compared to healthy controls. However, it is unknown whether there is a change in dysbiosis across the stages of diabetic chronic kidney disease. We investigated a cross-sectional study of patients with early and late diabetes associated chronic kidney disease to identify possible microbial differences between these two groups and across each of the stages of diabetic chronic kidney disease. (2) Methods: This cross-sectional study recruited 95 adults. DNA extracted from collected stool samples were used for 16S rRNA sequencing to identify the bacterial community in the gut. (3) Results: The phylum Firmicutes was the most abundant and its mean relative abundance was similar in the early and late chronic kidney disease group, 45.99 ± 0.58% and 49.39 ± 0.55%, respectively. The mean relative abundance for family Bacteroidaceae, was also similar in the early and late group, 29.15 ± 2.02% and 29.16 ± 1.70%, respectively. The lower abundance of Prevotellaceae remained similar across both the early 3.87 ± 1.66% and late 3.36 ± 0.98% diabetic chronic kidney disease groups. (4) Conclusions: The data arising from our cohort of individuals with diabetes associated chronic kidney disease show a predominance of phyla Firmicutes and Bacteroidetes. The families Ruminococcaceae and Bacteroidaceae represent the highest abundance, while the beneficial Prevotellaceae family were reduced in abundance. The most interesting observation is that the relative abundance of these gut microbes does not change across the early and late stages of diabetic chronic kidney disease, suggesting that this is an early event in the development of diabetes associated chronic kidney disease. We hypothesise that the dysbiotic microbiome acquired during the early stages of diabetic chronic kidney disease remains relatively stable and is only one of many risk factors that influence progressive kidney dysfunction.
DOI: 10.3390/biomedicines9010019
ORCID: 0000-0002-4376-9720
Journal: Biomedicines
PubMed URL: 33383810
ISSN: 2227-9059
Type: Journal Article
Subjects: chronic kidney disease
gut microbiome
Appears in Collections:Journal articles

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