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Title: | Use of a High Protein Enteral Nutrition Formula to Increase Protein Delivery to Critically Ill Patients: A Randomized, Blinded, Parallel-group, Feasibility Trial. | Austin Authors: | Chapple, Lee-Anne S;Summers, Matthew J;Bellomo, Rinaldo ;Chapman, Marianne J;Davies, Andrew R;Ferrie, Suzie;Finnis, Mark E;Hurford, Sally;Lange, Kylie;Little, Lorraine;O'Connor, Stephanie N;Peake, Sandra L;Ridley, Emma J;Young, Paul J;Williams, Patricia J;Deane, Adam M | Affiliation: | Medical Research Institute of New Zealand, Wellington, New Zealand The University of Melbourne, Melbourne Medical School, Department of Medicine and Radiology, Royal Melbourne Hospital, Parkville, Australia Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia Intensive Care Unit, Frankston Hospital, Australia Intensive Care Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia Department of Nutrition & Dietetics, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia National Health and Medical Research Council of Australia, Centre for Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia Intensive Care |
Issue Date: | May-2021 | Date: | 2020-12-09 | Publication information: | JPEN. Journal of Parenteral and Enteral Nutrition 2021; 45(4): 699-709 | Abstract: | International guidelines recommend critically ill adults receive more protein than most usually receive. We aimed to establish the feasibility of a trial to evaluate whether feeding protein to international recommendations would improve outcomes, in which one group received protein doses representative of international guideline recommendations (high protein) and the other received doses similar to usual practice. We conducted a prospective, randomized, blinded, parallel-group feasibility trial across six intensive care units (ICUs). Critically ill mechanically ventilated adults expected to receive enteral nutrition (EN) for ≥2 days were randomized to receive EN containing 63 or 100 g protein/liter for ≤28 days. Data are mean (standard deviation) or median [interquartile range]. The recruitment rate was 0.35 (0.13) patients/day with 120 patients randomized and data available for 116 (n = 58 per group). Protein delivery was greater in the high protein group (1.52 (0.52) vs 0.99 (0.27) g/kg IBW/day; difference 0.53 (95% CI 0.38 to 0.69) g/kg IBW/day), with no difference in calorie delivery (difference -26 (95% CI -190 to 137) kcal/kg IBW/day). There were no between-group differences in the duration of feeding (8.7 (7.3) vs 8.1 (6.3) days) and blinding of the intervention was confirmed. There were no differences in clinical outcomes including 90-day mortality (14/55 (26%) vs 15/56 (27%)); risk difference = -1.3 (95% CI -17.7 to 15.0) %. It is feasible to conduct a multi-center blinded trial comparing the delivery of protein at international guideline recommended levels to doses similar to usual care during critical illness. This article is protected by copyright. All rights reserved. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/25511 | DOI: | 10.1002/jpen.2059 | ORCID: | 0000-0002-9818-2484 0000-0002-7922-5717 0000-0002-7620-5577 |
Journal: | JPEN. Journal of Parenteral and Enteral Nutrition | PubMed URL: | 33296079 | Type: | Journal Article | Subjects: | Enteral feeding critical illness nutrition protein |
Appears in Collections: | Journal articles |
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