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Title: Epilepsy risk in offspring of affected parents; a cohort study of the "maternal effect" in epilepsy.
Austin Authors: Dreier, Julie W;Ellis, Colin A;Berkovic, Samuel F ;Cotsapas, Chris;Ottman, Ruth;Christensen, Jakob
Affiliation: Epilepsy Research Centre
Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Departments of Epidemiology and Neurology, and the G. H. Sergievsky Center, Columbia University, New York, New York, USA
Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York, USA
Centre for Integrated Register-based Research, CIRRAU, Aarhus University, Aarhus, Denmark
Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA
National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus BSS, Aarhus University, Aarhus, Denmark
Departments of Neurology and Genetics, Yale School of Medicine, New Haven, USA
Issue Date: Jan-2021
Date: 2020-11-29
Publication information: Annals of Clinical and Translational Neurology 2021; 8(1): 153-162
Abstract: To assess whether the risk of epilepsy is higher in offspring of mothers with epilepsy than in offspring of fathers with epilepsy. In a prospective population-based register study, we considered all singletons born in Denmark between 1981 and 2016 (N = 1,754,742). From the Danish National Patient Register since 1977, we identified epilepsy diagnoses in all study participants and their family members. Cox regression models were used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CI), adjusted for relevant confounders. We included 1,754,742 individuals contributing > 30 million person-years of follow-up. The incidence rate of epilepsy in offspring of unaffected parents was 78.8 (95% CI: 77.8-79.8) per 100,000 person-years, while the corresponding rate in offspring with an affected father was 172 per 100,000 person-years (95% CI: 156-187) and in offspring with an affected mother was 260 per 100,000 person-years (95% CI: 243-277). Having an affected mother was associated with a 1.45-fold (95% CI: 1.30-1.63) higher risk of epilepsy in the offspring, compared to having an affected father. This maternal effect was found both in male (HR = 1.39, 95% CI: 1.19-1.62) and female offspring (HR = 1.53, 95% CI: 1.30-1.80), and across various ages at onset in the offspring. The maternal effect was also found in familial epilepsies (i.e. where the affected parent had an affected sibling; HR = 1.50, 95% CI: 1.04-2.16). We found a clear maternal effect on offspring risk of epilepsy in this nationwide cohort study.
DOI: 10.1002/acn3.51258
ORCID: 0000-0002-9339-4170
Journal: Annals of Clinical and Translational Neurology
PubMed URL: 33249752
Type: Journal Article
Appears in Collections:Journal articles

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